四川省绵阳市2013—2016年耐药结核筛查情况分析

Analysis of situation of anti-TB drug resistance in Mianyang, Sichuan, 2013-2016

目的分析绵阳市2013-2016年报告的肺结核耐药筛查情况,为制定结核病防控相关措施提供科学依据。方法从中国疾控预防控制信息系统结核病信息管理系统中,收集绵阳市2013年1月-2016年12月期间报告的全部肺结核耐药筛查者的年龄、职业、药敏等信息,药敏试验采用WHO《结核病耐药监测指南》推荐的比例法,不同年份、地区、性别、年龄、职业及可疑者登记分类间的耐药情况比较用χ^2检验。结果2013年1月-2016年12月,共报告1 666例耐药筛查结果,其中结核分枝杆菌标本1 648份,非结核分枝杆菌13例,污染5例,总耐药率21.48%(354/1 648)。总耐药率在不同年份、地区和性别的差异无统计学意义(P>0.05);在不同年龄、职业和登记分类的总耐药率差异有统计学意义(P<0.05)。结论绵阳市耐药结核病高危人群和重点人群耐药流行相对严重,应继续加强耐药结核筛查工作和结核病防治健康教育宣传工作。

Objective To investigate the prevalence and risk factors of the tuberculosis( TB) in Mianyang City from2013-2016, to provide evidences for the prevention of TB. Methods The data of the age, occupation, drug sensitivity of the resistance screeners for tuberculosis were collected from the"China Disease Prevention and Control Information System"TB management information system from January 2013 to December 2016. Drug susceptibility test was conducted using the proportion method recommended by WHO guidelines for TB resistance monitoring. Chi-square test was performed to compare drug resistance among different years, regions, sex, age, occupation, and registration classify suspicious patients.Results During January 2013 to December 2016, 1 666 TB cases of drug resistance were reported, among them, 1 648 cases of Mycobacterium tuberculosis, 13 cases were non-Mycobacterium tuberculosis, 5 cases were polluted. The total drug-resistant rate was 21.48%(354/1 648). There were no significant difference in total drug resistance among different years, regions, and sexes(P>0.05). There were significant differences in total drug resistance rates among different ages, occupations and registered classifications(P<0.05). Conclusion The prevalence of drug resistant TB is relatively high in the risk groups and a key population for TB in Mianyang City. Thus drug resistant surveillance on TB should be strengthened continuously and enhancement of health education for patients.