急性胰腺炎患者血浆D-二聚体变化与病情严重程度的相关分析

Correlation between Changes of Plasma D-dimer and Severity of Severity in Patients with Acute Pancreatitis

目的探讨急性胰腺炎患者血浆D-二聚体变化与病情严重程度的相关性。方法方便选取该院2018年1月—2019年1月接诊的急性胰腺炎患者60例,将其按照病情的严重程度分成轻症组32例、重症组28例。检测不同时间段患者的血浆D-二聚体变化水平(D-D)。同时对比患者的实验室指标。结果轻症组患者入院时(0.82±0.28)μg/mL、入院3 d(0.88±0.26)μg/mL、入院7 d(0.52±0.05)μg/mL,重症组分别为(1.38±0.31)μg/mL、(1.66±0.45)μg/mL、(1.01±0.18)μg/mL,差异有统计学意义(t=8.043、9.005、15.737,P<0.05);轻症组患者的PT、APTT、PCV、BG、Alb、白细胞计数、血钙等均优于对照组,差异有统计学意义(P<0.05);进一步研究可发现,急性胰腺炎患者的D-D水平与实验室指标密切相关,其中与BG、白细胞计数、APTT、PT为正相关,与Alb、PCV、血钙为负相关,患者病情越严重,D-D水平越高。结论血浆D-二聚体水平能够反映急性胰腺炎患者的病情进展程度,操作简单,其水平超过正常值的两倍对于判断疾病有重要意义,建议急性胰腺炎患者入院后尽早检测血浆D-二聚体水平,帮助临床医师评价病情进展。

Objective To investigate the relationship between plasma D-dimer changes and severity of severity in patients with acute pancreatitis.Methods convenient select sixty patients with acute pancreatitis who were admitted to our hospital from January 2018 to January 2019 were enrolled.According to the severity of the disease,32 patients were divided into mild group and 28 patients in severe group.Plasma D-dimer change levels(D-D)were measured in patients at different time periods.Also compare the patient's laboratory indicators.Results The patients in the mild group were hospitalized(0.82±0.28)μg/mL,admitted to hospital for 3 days(0.88±0.26)μg/mL,admitted for 7 days(0.52±0.05)μg/mL,and the severe group were(1.38±0.31)μg/mL,(1.66±0.45)μg/mL,(1.01±0.18)μg/mL,,the difference was statistically significant(t=8.043,9.005,15.737,P<0.05);PT,APTT,PCV,BG,Alb,white blood cell count,blood in patients with mild disease calcium and other factors were better than the control group,the difference was statistically significant(P<0.05);further studies found that the DD level of patients with acute pancreatitis was closely related to laboratory indicators,which were positively correlated with BG,white blood cell count,APTT,PT,and Alb,PCV,blood calcium is negatively correlated,and the more severe the patient's condition,the higher the DD level.Conclusion The plasma D-dimer level can reflect the progress of patients with acute pancreatitis.The operation is simple,and its level is more than twice the normal value.It is important to judge the disease.It is recommended that patients with acute pancreatitis detect plasma D-II as soon as possible after admission.The level of the polymer helps clinicians evaluate the progress of the disease.