根除幽门螺杆菌对功能性消化不良的治疗效果分析

Analysis of the Therapeutic Effect of Eradication of Helicobacter Pylori on Functional Dyspepsia

目的探讨功能性消化不良患者的根除幽门螺杆菌治疗效果。方法方便选取该院2017年5月—2018年7月期间消化科门诊治疗的124例功能性消化不良患者作为研究对象,分为观察组(根除幽门螺杆菌)和对照组(常规治疗)各62例,观察两组患者的治疗效果。结果与治疗前相比,两组患者治疗后的临床症状得到明显改善,主要体现为上腹痛综合征(EPS)评分和餐后不适综合征(PDS)评分的降低(P<0.05)。与对照组相比,观察组患者的治疗有效率(93.55%vs 79.03%)相对更高(χ2=5.521,P<0.05),复发率(1.61%vs 12.90%)、EPS评分[(1.29±0.43)分vs(1.38±0.57)分]、PDS评分[(1.37±0.41)分vs(1.50±0.64)分]、汉密尔顿抑郁量表(HAMD)评分[(9.92±1.04)分vs(14.97±2.23)分]相对更低(χ2=4.313,t=5.642、5.239、5.185,P<0.05),而胃肠功能恢复时间[(3.95±0.82)d vs(6.45±1.47)d]、症状消失时间[(4.41±1.22)d vs(7.02±2.64)d]相对更短(t=5.162、5.394,P<0.05)。结论根除幽门螺杆菌是治疗功能性消化不良的有效方法,能够避免幽门螺杆菌对于疾病的影响,进而提高疾病的治疗效果。

Objective To investigate the therapeutic effect of eradication of Helicobacter pylori in patients with functional dyspepsia.Methods convenient select a total of 124 patients with functional dyspepsia who were treated in the outpatient department of the Department of Gastroenterology from May 2017 to July 2018 were enrolled in the study.They were divided into observation group(eradication of Helicobacter pylori)and control group(conventional treatment).For example,the therapeutic effects of the two groups of patients were observed.Results Compared with before treatment,the clinical symptoms of the two groups were significantly improved after treatment,which was mainly reflected in the lowering of upper abdominal pain syndrome(EPS)score and postprandial discomfort syndrome(PDS)score(P<0.05).Compared with the control group,the treatment efficiency of the observation group(93.55%vs 79.03%)was relatively higher(χ2=5.521,P<0.05),the recurrence rate(1.61%vs 12.90%),EPS score[(1.29±0.43)points vs(1.38±0.57)points],PDS scores[(1.37±0.41)points vs(1.50±0.64)points],Hamilton Depression Scale(HAMD)scores[(9.92±1.04)points vs(14.97±2.23)points]were relatively lower(χ2=4.313,t=5.642,5.239,5.185,P<0.05),while gastrointestinal function recovery time[(3.95±0.82)d vs(6.45±1.47)d],the symptom disappearance time[(4.41±1.22)d vs(7.02±2.64)d]was relatively shorter(t=5.162,5.394,P<0.05).Conclusion Eradication of Helicobacter pylori is an effective method for the treatment of functional dyspepsia,which can avoid the impact of Helicobacter pylori on the disease,and thus improve the therapeutic effect of the disease.