NF-κB通路中基因多态性与肺癌易感性的Meta分析

Genetic loci in the NF-κB pathway and lung cancer susceptibility:a meta-analysis

目的系统评价NFKB1基因rs4648127、rs28362491位点和NFKBIA基因rs696位点多态性与肺癌易感性的关联性。方法计算机检索Web of Science、PubMed、VIP、CNKI和WanFang Data数据库,搜集有关NFKB1和NFKBIA基因多态性与肺癌发生相关性的病例-对照研究,检索时限均为建库至2018年11月。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Stata 12.0软件进行Meta分析。结果最终纳入7个病例-对照研究。Meta分析结果显示,NFKB1基因rs4648127多态性和肺癌易感性无相关性[C vs. T:OR=1.065,95%CI(0.323,3.512),P=0.918]。但医院人群rs28362491多态性[D vs. I:OR=1.290,95%CI(1.117,1.489),P=0.001;DD vs. II:OR=1.707,95%CI(1.273,2.289),P<0.001;DD vs. ID+II:OR=1.409,95%CI(1.100,1.806),P=0.008]与肺癌易感性呈正相关。NFKBIA基因rs696多态性[A vs. G:OR=1.215,95%CI(1.105,1.336),P<0.001;AA vs. GG:OR=1.438,95%CI(1.194,1.731),P<0.001;GG vs. AG+AA:OR=1.566,95%CI(1.341,1.829),P<0.001]与肺癌易感性正相关。结论当前证据显示,NFKB1基因rs4648127多态性可能与肺癌发生无关联;医院人群的NFKB1基因rs28362491多态性和NFKBIA基因rs696多态性可能与肺癌发生呈正相关。受纳入研究数量和质量的限制,上述结论尚待更多高质量研究予以验证。

Objectives To systematically review the correlation between NFKB1 gene, NFKBIA gene and lung cancer susceptibility. Methods Web of Science, PubMed, VIP, CNKI and WanFang Data databases were electronically searched to collect case-control studies on the correlation between NFKB1 gene rs4648127, rs28362491 polymorphisms and NFKBIA gene rs696 polymorphism and lung cancer susceptibility from inception to November, 2018. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies;then, meta-analysis was performed by using Stata 12.0 software. Results A total of 7 case-control studies were included. The results of metaanalysis showed that: no correlation was found between rs4648127 and lung cancer susceptibility(C vs. T: OR=1.065,95%CI 0.323 to 3.512, P=0.918). A positive correlation was found in hospital population between rs28362491(D vs. I:OR=1.290, 95%CI 1.117 to 1.489, P=0.001;DD vs. II: OR=1.707, 95%CI 1.273 to 2.289, P<0.001;DD vs. ID+II: OR=1.409,95%CI 1.100 to 1.806, P=0.008) and lung cancer. Rs696 polymorphism(A vs. G: OR=1.215, 95%CI 1.105 to 1.336,P<0.001;AA vs. GG: OR=1.438, 95%CI 1.194 to 1.731, P<0.001;GG vs. AG+AA: OR=1.566, 95%CI 1.341 to 1.829,P<0.001) was correlated with lung cancer susceptibility. Conclusions Current evidence shows that NFKB1 gene rs4648127 may not be associated with lung cancer. The rs28362491 pdymorphism of NFKB1 gene in hospital population and rs696 pdymorphism of NFKBIA gene may be positively correlated with lung cancer susceptibility. Due to limited quality and quantity of the included studies, more high quality studies are required to verify above conclusions.