血同型半胱氨酸水平与老年痴呆的相关性研究

Study on correlation between plasma homocysteine level and senile dementia

目的探讨血同型半胱氨酸(Hcy)水平与老年痴呆的相关性。方法选取96例老年痴呆患者作为研究组,其中按痴呆类型分为血管性痴呆35例、阿尔茨海默病32例、帕金森病痴呆29例,按病情严重程度分为重度14例、中度38例、轻度44例;选择同期就诊于本院的32例非痴呆老年患者作为对照组。检测各组血Hcy水平,比较对照组与不同痴呆程度、不同痴呆类型患者血浆Hcy水平的差异。结果研究组轻、中、重度患者的血Hcy水平分别为(14.93±3.97)、(18.72±5.51)、(21.79±2.24)μmol/L,均高于对照组的(12.79±5.26)μmol/L,差异均有统计学意义(P<0.05);中度、重度患者血Hcy水平高于轻度患者,重度患者血Hcy水平高于中度患者,差异有统计学意义(P<0.05)。研究组血管性痴呆、阿尔茨海默病、帕金森病痴呆患者血Hcy水平分别为(20.32±5.79)、(17.41±4.23)、(15.42±3.39)μmol/L,均高于对照组的(12.79±5.26)μmol/L,差异均有统计学意义(P<0.05);血管性痴呆患者血Hcy水平高于阿尔茨海默病患者和帕金森病痴呆患者,差异均有统计学意义(P<0.05)。结论血Hcy水平越高患者认知功能减退越严重,检测血Hcy水平可有效区分痴呆类型,为临床治疗提供指导意见。

Objective To discuss the correlation between plasma homocysteine(Hcy) level and senile dementia. Methods A total of 96 cases of senile dementia were taken as research group. According to the type of dementia, they were divided into vascular dementia in 35 cases, Alzheimer’s disease in 32 cases and Parkinson’s disease in 29 cases. According to severity of disease into 14 severe cases, 38 moderate cases and 44 mild cases. 32 non-dementia elderly patients visited our hospital at the same time were selected as the control group. The levels of plasma Hcy in each group were detected, and the difference of plasma Hcy level between control group and patients with different dementia degrees and types was compared. Results The plasma Hcy level were(14.93±3.97),(18.72±5.51) and(21.79±2.24) μmol/L respectively in mild, moderate and severe dementia patients of the research group, which was higher than(12.79±5.26) μmol/L in the control group. Their difference was statistically significant(P<0.05). The plasma Hcy level in moderate and severe patients was higher than that in mild patients, and that in severe patients was higher than moderate patients. Their difference was statistically significant(P<0.05). The plasma Hcy level were(20.32±5.79),(17.41±4.23) and(15.42± 3.39) μmol/L respectively in patients with vascular dementia, Alzheimer’s disease and Parkinson’s disease of the research group, which was higher than(12.79±5.26) μmol/L in the control group. Their difference was statistically significant(P<0.05). The plasma Hcy level in patients with vascular dementia was higher than those with Alzheimer’s disease and Parkinson’s disease, and the plasma Hcy level in patients with Alzheimer’s disease was higher than that with Parkinson’s disease. Their difference was statistically significant(P<0.05). Conclusion The higher the level of plasma Hcy, the more serious the cognitive impairment. Detecting the level of plasma Hcy can effectively distinguish the types of dementia and provide guidance for clinical treatment.