口服药物膜渗透性评价方法及其在中药研究中的应用进展

Membrane permeability evaluation method of oral drugs and their application progress in Chinese materia medica

中药多以口服途径给药,药物的生物膜(如细胞膜等)通透性反映药物在体内的吸收转运能力,采用适当的药物渗透模型对中药活性成分进行膜渗透性评价,对明确中药活性成分吸收转运机制,阐明中药的药效物质基础以及中药的剂型设计具有一定的指导意义。总结了口服药物膜渗透性评价方法,并对其在中药研究中的应用进行了综述和归纳,以供参考。

Chinese materia medica is mostly taken orally.The permeability of a drug’s biofilm(e.g.cell membrane)reflects its ability of absorption and transportation in the body.It is of guiding significance to evaluate the membrane permeability of the active components of Chinese materia medica by using appropriate drug permeation model,so as to clarify,the oral absorption and transport mechanism of active ingredients,pharmacodynamic substance basis and dosage form design.The evaluation method of oral drug membrane permeability,as well as the application of various methods in Chinese medicine was summarized for reference in this review.