2004-2018年基因编辑领域主要国家学术论文分析

Analysis of Major National Academic Papers in the Field of Gene Editing in 2004-2018

以Web of Science核心合集中的SCIE数据库为数据来源,利用TDA、SPSS、VOSviewer、UCINET等工具,结合文献计量分析、可视化分析、社会网络分析等方法,分别从总量、引证、主题3个维度对2004-2018年基因编辑领域20个主要国家的学术论文进行研究。结果表明,基因编辑领域的研究工作已进入快速发展阶段,各国在不同维度有着不同的表现。美国在学术论文总量方面最多,中国的发文增速最快;中美两国在学术论文总量和被引总次数上都稳执牛耳,瑞典、荷兰、美国等国家历年论文的被认可度较高;20个国家的研究主题基本概括为神经学与遗传学、癌症抑制、合成生物学与基因工程、结构多样性与病毒防御4个范畴,研究热点主要集中在CRISPR/Cas、Zinc-finger、核酸酶、基因敲除、癌症抑制等方面,美国、中国、日本、德国和法国是核心研究力量,研究范围非常广泛。

With the SCIE database in the core collection of Web of Science as the data source,TDA,SPSS,VOSviewer,UCINET and other tools,combined with bibliometric analysis,visual analysis,social network analysis and other methods,this paper studied the academic papers of 20 major countries in the field of gene editing from 2004 to 2018 in three dimensions:total,citation and topic.The results show that the research on gene editing has entered a rapid phase,and different countries have different performance in different dimensions.The United States has the largest number of academic papers,and China has the fastest growth rate.China and the United States are the top two countries in terms of the total number of academic papers and the total number of cited papers.Sweden,the Netherlands,the United States and other countries have high recognition of papers over the years.20 countries research topics summed up basic neurology and genetics,cancer inhibition,synthetic biology and genetic engineering,structure diversity and virus defense four categories,research focus mainly concentrated in the CRISPR/Cas,Zinc-finger,nuclease,gene knockout,cancer inhibition,etc.,the United States,China,Japan,Germany and France is the core research strength,research scope is very broad.