维生素A缺乏与小儿反复呼吸道感染的相关性

Correlation between Vitamin A deficiency and recurrent respiratory tract infection in children

目的分析维生素A缺乏、免疫及炎症因子与小儿反复呼吸道感染的相关性。方法选择2017年1月-2018年1月遵义市妇幼保健院收治的反复呼吸道感染患儿74例为病例组,选择同期健康体检儿童74名为对照组。检测两组儿童维生素A缺乏情况,比较两组儿童血清白细胞介素-1(IL-1)、超敏C-反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)与免疫球蛋白G(IgG)水平,对维生素A、炎症因子与小儿反复呼吸道感染进行Pearson相关性分析。结果病例组患儿维生素A缺乏发生率35.14%,维生素A可疑性缺乏发生率32.43%,均高于对照组,差异有统计学意义(P<0.05)。病例组患儿IL-1、IgG及淋巴细胞计数指标水平均低于对照组;血清hs-CRP、TNF-α水平高于对照组,差异有统计学意义(P<0.05)。维生素A、IL-1、IgG、淋巴细胞计数与小儿反复呼吸道感染呈显著负相关;hs-CRP、TNF-α与小儿反复呼吸道感染呈显著正相关(P<0.05)。结论反复呼吸道感染患儿存在维生素A缺乏症状,其血清免疫指标低于正常儿童,炎症因子高于正常儿童。

OBJECTIVE To analyze the correlation between the vitamin A deficiency,immunity,inflammatory factors and recurrent respiratory tract infection.METHODS A total of 74 children with recurrent respiratory tract infection who were treated in Zunyi City Maternal and Child Health Hospital from Jan 2017 to Jan 2018 were chosen as the car group,meanwhile,74 healthy children who received physical examination were assigned as the control group.The incidence of vitamin A deficiency was determined,the levels of serum interleukin-1(IL-1),high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)and immunoglobulin G(IgG)were compared between the two groups of children.Pearson correlation analysis was performed for the vitamin A,inflammatory factors and recurrent respiratory tract infection.RESULTS The incidence rate of vitamin A deficiency of the case group was 35.14%,significantly higher than that of the control group;the incidence rate of suspected vitamin A deficiency of the case group was 32.43%,significantly higher than that of the control group significantly(P<0.05).The levels of IL-1,IgG and lymphocytes of the case group were significantly lower than those of the control group;the levels of serum hs-CRP and TNF-αof the case group were significantly higher than those of the control group(P<0.05).The recurrent respiratory tract infection in the children was negatively correlated with the vitamin A,IL-1,IgG and lymphocytes counts;the recurrent respiratory tract infection in the children was positively correlated with the hs-CRP and TNF-α(P<0.05).CONCLUSION The children with recurrent respiratory tract infection,of whom the serum immune indexes are lower than those of the normal children and inflammatory factors are higher than those of the normal children,have the vitamin A deficiency.