某生殖中心就诊不孕患者支原体感染及其药物敏感性研究

Mycoplasma infection in infertility patients of a reproductive center and drug susceptibility

目的分析某生殖中心就诊不孕患者支原体感染及其药物敏感性,为临床防治不孕症提供参考。方法回顾性分析2016年1月-2018年1月于遵义医学院附属医院生殖中心就诊的186例不孕患者临床资料,统计支原体感染率,分析不同浓度抗菌药物敏感率、耐药性。结果186例不孕妇女共检出154例支原体感染,感染率为82.80%,其中解脲脲支原体(Uu)感染124例占80.52%,人支原体(Mh)+Uu感染22例占14.29%,Mh感染8例占5.19%(P<0.05)。Uu敏感率最高为交沙霉素,耐药率最高为阿奇霉素,Uu对交沙霉素、克拉霉素、强力霉素、壮观霉素、加替沙星、美满霉素敏感率较高;Uu对阿奇霉素、环丙沙星、甲砜霉素耐药率较高。Mh+Uu敏感率最高为壮观霉素、美满霉素、强力霉素,耐药率最高为罗红霉素。Mh敏感率最高为交沙霉素、壮观霉素,耐药率最高为阿奇霉素、克拉霉素、罗红霉素。结论不孕妇女支原体感染率较高,其中Uu感染情况较为严重,对不孕妇女应该提高支原体检测及药敏试验力度,临床治疗支原体感染可以首选强力霉素、交沙霉素、壮观霉素、克拉霉素抗菌药物。

OBJECTIVE To explore the Mycoplasma infection in the infertility patients of a reproductive center and analyze the drug susceptibility so as to provide guidance for prevention and trentment of infertility.METHODS The clinical data of 186 infertility patients who were treated in the reproductive center from Jan 2016 to Jan 2018 were retrospectively analyzed,the incidence of Mycoplasma infection was statistically analyzed,and the drug susceptibility rates and drug resistance rates to different concentrations of antibiotics were observed.RESULTS Of the 186 infertility patients,154 had Mycoplasma infection,with the infection rate 82.80%,124(80.52%)of whom had Ureaplasma urealyticum(Uu)infection,22(14.29%)had Mycoplasma hominis(Mh)plus Uu infection,and 8(5.19%)had Mh infection(P<0.05).The drug susceptibility rate of the Uu to josamycin was the highest,the drug resistance rate to azithromycin was the highest,and the Uu strains were highly sensitive to josamycin,clarithromycin,doxycycline,spectinomycin,gatifloxacin and minocycline;the Uu strains were highly resistant to azithromycin,ciprofloxacin and thiamphenicol.The drug susceptibility rates of Mh plus Uu to spectinomycin,minocycline and doxycycline were the highest,and the drug resistance rate to roxithromycin was the highest.The drug susceptibility rates of the Mh strains to josamycin and spectinomycin were the highest,and the drug resistance rates to azithromycin,clarithromycin and roxithromycin were the highest.CONCLUSION The incidence of Mycoplasma infection is relatively high in the infertile women,and the Uu infection is severe.It is necessary to focus on the detection of Mycoplasma and conduct the drug susceptibility testing;doxycycline,josamycin,spectinomycin and clarithromycin are preferred for the clinical treatment of Mycoplasma infection.