TKTL1在结肠腺瘤、结肠癌中的表达及其临床意义

Expression and Clinical Significance of TKTL1 in Colon Adenoma and Colon Cancer

背景:各种肿瘤组织均有TKTL1表达,其表达水平与肿瘤侵袭转移和预后密切相关。目的:探讨TKTL1在结肠腺瘤、结肠癌中的表达及其临床意义。方法:选取2015年3月-2018年5月至淄博市第一医院行结肠镜检查证实的30例正常结肠黏膜、84例结肠腺瘤以及手术证实的84例结肠癌组织,以免疫组化法检测TKTL1蛋白表达,并分析TKTL1表达与结肠腺瘤、结肠癌临床病理参数的关系。结果:结肠腺瘤、结肠癌的TKTL1表达率显著高于正常结肠黏膜(57. 1%、85. 7%对13. 3%,P <0. 01),且结肠癌TKTL1表达率明显高于结肠腺瘤(P <0. 01)。TKTL1表达与结肠腺瘤患者的性别、年龄、病理类型和病理特征无关(P> 0. 05)。TKTL1表达与结肠癌患者的性别、年龄、组织分化程度无关(P> 0. 05),而与TNM分期、远处转移、淋巴结转移、浸润深度相关(P <0. 05)。结论:TKTL1在结肠腺瘤、结肠癌中的表达显著高于正常结肠组织,且与结肠癌分期、转移有相关性,推测TKTL1表达与结肠癌的发生、发展密切相关。

Background: TKTL1 is expressed in various tumor tissues, and its expression level is closely related to tumor invasion, metastasis and prognosis. Aims: To investigate the expression and clinical significance of TKTL1 in colon adenoma and colon cancer. Methods: Thirty normal colon mucosa, 84 colon adenoma confirmed by colonoscopy, and 84 colon cancer tissues diagnosed by surgery from March 2015 to May 2018 at the First Hospital of Zibo were enrolled. Protein expression of TKTL1 was detected by immunohistochemistry, and its relationship with clinicopathological parameters in patients with colon adenoma, colon cancer were analyzed. Results: Rate of TKTL1 expression was significantly increased in colon adenoma and colon cancer than in normal colon mucosa (57.1%, 85.7% vs. 13.3%, P<0.01), and rate of TKTL1 expression in colon cancer was significantly higher than that in colon adenoma (P<0.01). The expression of TKTL1 was not related to gender, age, pathological type, pathological feature in patients with colon adenoma (P>0.05). The expression of TKTL1 was not related to gender, age, differentiation in patients with colon cancer (P>0.05), while was related to TNM staging, distant metastasis, lymph node metastasis and depth of infiltration (P<0.05). Conclusions: The expression of TKTL1 in colon adenoma and colon cancer is significantly higher than that in normal colon tissues, and is related to the staging and metastasis of colon cancer. The expression of TKTL1 is closely related to the occurrence and development of colon cancer.