肿瘤坏死因子-α在非酒精性脂肪性肝病进展中的作用

Role of Tumor Necrosis Factor-α in Progression of Non-alcoholic Fatty Liver Disease

非酒精性脂肪性肝病(NAFLD)是代谢综合征的肝脏表现。“二次打击”学说显示细胞因子在NAFLD的发病机制中起有非常重要的作用。肿瘤坏死因子-α(TNF-α)是肿瘤坏死因子家族中的重要成员,其来源广泛,具有多种生物学效应。体内TNF-α的表达具有组织特异性,参与各项细胞活动。低浓度TNF-α参与抵抗体内感染,而过量TNF-α会破坏机体的免疫平衡,与其他炎症因子形成病理损伤。本文就TNF-α在NAFLD进展中的作用作一综述。

Non-alcoholic fatty liver disease(NAFLD)is a liver manifestation of the metabolic syndrome.The"second strike"theory implies that cytokines play vital roles in the pathogenesis of NAFLD.Tumor necrosis factor-α(TNF-α),an important member of the tumor necrosis factor family,is widely available and has various biological effects.The expression of TNF-αin vivo is tissue-specific and participates in various cellular activities.Low concentration of TNF-αis involved in anti-inflammation,while excessive TNF-αimpairs systematic immune balance and contributes to pathological changes along with other inflammatory cytokines.This article reviewed the role of TNF-αin progression of NAFLD.