摘要
目的本次试验将分析放射性核素89SrCl2(氯化锶)与云克(锝[99Tc]亚甲基二膦酸盐)治疗恶性肿瘤骨转移的临床改善效果。方法本次试验选取了2018年1月-2018年12月在本院进行治疗的患者为对象,经过检查后均已确诊为恶性肿瘤骨转移,而符合试验要求的人数有78例,采用随机数字表法将患者分为对照1组、对照2组与观察组各26例。对照1组患者采用放射性核素89SrCl2,对照2组患者采用云克治疗,观察组则为两种方式的联合策略,主要比较患者的骨转移缓解率、癌痛改善以及不良反应等。结果从改善结果上看,观察组的骨转移缓解率为96.2%,优于对照1组和对照2组的65.4%、69.2%,P<0.05。在癌痛的改善方面,观察组为92.3%,高于对照1组和对照2组的65.4%、73.1%,联合治疗措施优于单一方案,差异具有统计学意义,P<0.05。在不良反应的发生率上组间差异不大,均具有良好的安全性。结论采用联合应用措施对恶性肿瘤骨转移患者的治疗更为有效,能够缓解病情,改善病痛,值得推广应用。
Objective To study the effect of radionuclide 89Sr Cl2(dichloride)and Yunke(99Tc-MDP)in the treatment of bone metastasis of malignant tumor.Methods This test selected the patients treated in our hospital from January 2018 to December 2018 as the target.After the examination,it was confirmed that the bone metastasis of the malignant tumor was confirmed,and the number of the patients meeting the requirements of the trial was 78.The patients were divided into control group 1,control group 2 and observation group with random number table,each with 26 cases.In the control group,the radionuclide 89SrCl2 was used in the control group 1,and the patients in the control group 2 were treated with Yunke,and the observation group was treated with a two-way combined treament.The bone metastasis of the patients,the improvement of the cancer pain and the adverse reaction were observed and evaluated.Results From the results of the improvement,the effect of the control group 1 and the control group 2 on the improvement of the bone metastasis of the patients was inferior to that of the observation group,that is,the remission rate of the bone metastasis in the observation group was 96.2%,which was better than that of the control group 1(65.4%)and control group 2(69.2%),P<0.05.In addition,in the improvement of cancer pain,92.3%in the observation group,65.4%for the control group,and 73.1%for the control group 2.The combination therapy is superior to a single regimen,the difference was significant(P<0.05).Finally,there was no inter-group difference in the incidence of adverse reactions Large,all have good security guarantee.Conclusion The combined application is more effective in the treatment of bone metastasis of malignant tumor,which can relieve the disease and improve the pain,and it is worth popularizing and applying.
作者
张伟
ZHANG Wei(Department of Nuclear Medicine,Chifeng Hospital,Chifeng Inner Mongolia 024000,China)
出处
《中国卫生标准管理》
2019年第23期76-78,共3页
China Health Standard Management