丙泊酚复合氯胺酮及芬太尼在小儿静脉麻醉中的应用研究

Application of Propofol Combined With Ketamine and Fentanyl in Intravenous Anesthesia in Children

目的研究探讨丙泊酚、氯胺酮及芬太尼联合应用在小儿静脉麻醉的应用效果,并评价安全性。方法将2016年6月-2017年12月间来我院行手术治疗的130例患儿随机分组,对照组患儿采用行丙泊酚、氯胺酮麻醉,而试验组行芬太尼、丙泊酚、氯胺酮麻醉,观察患儿在麻醉前后和手术中的心率变化情况以及出现的不良反应,并进行比较。结果结果显示,试验组的患儿麻醉后心率没有明显变化,而对照组患儿在麻醉前后心率起伏较大,且对照组患儿的心率明显高于试验组,P<0.05;试验组有2例患儿出现恶心,1例患儿出现呕吐,1例出现躁动,1例患儿舌头发生后坠,不良反应发生率为7.69%;对照组中有3例患儿出现呕吐,2例出现恶心,1例出现躁动,1例患儿舌头发生后坠,不良反应发生率为10.77%,两组患儿之间差异无统计学意义,P>0.05。结论对患儿行静脉麻醉时丙泊酚、氯胺酮及芬太尼联合应用的效果较好,安全性较高。

Objective To investigate the application effect of propofol,ketamine and fentanyl in intravenous anesthesia in children,and to evaluate the safety.Methods One hundred and thirty patients who underwent surgery in our hospital from June 2016 to December 2017 were randomized.The control group was anesthetized with propofol and ketamine,while the experimental group was anesthetized with fentanyl,propofol and ketamine.Heart rate changes and adverse reactions occurred before and after anesthesia were observed and compared.Results The results showed that there was no significant change in heart rate after anesthesia in the experimental group,but the heart rate of the control group was significantly higher before and after anesthesia,and the heart rate of the control group was significantly higher than that of the experimental group,P<0.05.Two patients developed nausea,one patient developed vomiting,one patient developed agitation,and one patient developed a tongue fall.The incidence of adverse reactions was 7.69%.In the control group,3 patients developed vomiting and 2 patients developed Nausea,1 case of agitation,1 case of children with tongue fall,the incidence of adverse reactions was 10.77%,there was no significant difference between the two groups,P>0.05,not statistically significant.Conclusion The combination of propofol,ketamine and fentanyl is better in patients with intravenous anesthesia.