卵巢癌肿瘤微环境的三维细胞培养模型研究进展

Research progress in 3D cell culture model of ovarian cancer tumor microenvironment

卵巢癌(Ovarian cancer,OC)是一种具有侵袭性和致命性的癌症。越来越多的研究表明,肿瘤微环境(Tumor microenvironment,TME)通过各种机制参与促进卵巢癌发生、发展、免疫抑制和炎性反应。TME包括肿瘤血管和淋巴管,以及肿瘤细胞、间质细胞、免疫细胞和细胞外基质(ECM)等。本文结合近年来的文献报道,综述了目前常用的卵巢癌TME三维细胞培养模型,以及总结了许多不包含原始基质细胞的三维模型,旨在总结和寻找卵巢癌治疗的新途径和新方法。

Ovarian cancer(OC)is an aggressive and fatal cancer.A growing number of studies have shown that the tumor microenvironment(TME)is involved in the promotion and development of ovarian cancer,immunosuppression and inflammatory response through various mechanisms.TME includes tumor blood vessels and lymphatic vessels,as well as cancer cells,mesenchymal cells,immune cells,and extracellular matrix(ECM).Based on recent literature reports,this paper reviews the commonly used three-dimensional(3D)cell culture model of ovarian tumor microenvironment,and summarizes many 3D models that do not contain primitive stromal cells,aiming to find new approaches for ovarian cancer treatment.