MiR-26a在肺癌中的研究进展

Research progress of MiR-26a in lung cancer

肺癌的发病和死亡居全部恶性肿瘤的首位,同时肺癌患者的耐药情况愈来愈严峻,给国家经济和人民健康造成了极大负担。MiR-26a是一类小的非编码RNA,通过靶向调控相关蛋白与信使RNAs(mRNAs)而影响肺癌细胞的增殖、迁移和侵袭等生物学作用。本文旨在对miR-26a在肺癌中的作用机制进行详细阐述,为肺癌的治疗与耐药提供临床生物标志物。

The incidence and death of lung cancer rank first among all malignant tumors,and drug resistance of lung cancer patients is becoming more and more severe,which has caused a great burden on the national economy and people′s health.MiR-26a is a small class of non-coding RNA that affects the biological effects on proliferation,migration and invasion of lung cancer cells by targeting related proteins and messenger RNAs(mRNAs).This article aims to elaborate the mechanism of miR-26a in lung cancer and provides the clinical biomarkers for the treatment and drug resistance of lung cancer.