慢性精神分裂症血脂代谢特征及其与HS-CRP的关系

Characteristics of lipid metabolism in chronic schizophrenia and its relationship with HS-CRP

目的探讨慢性精神分裂症(SZ)患者血脂代谢特征以及其与超敏C反应蛋白(HSTRP)的相关性。方法本研究为多中心、横断面研究。纳入327例慢性精神分裂症患者及180例正常对照,比较患者组和对照组血胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDLT)、血清HSTRP水平的差异以及血脂异常的发生率;收集患者组人口学资料、临床资料,采用阳性和阴性综合征量表(PANSS)评定精神症状,分析血脂异常的危险因素;检测血清HS-FRP的水平,并分析HSTRP与患者发生血脂异常的相关性。结果患者组血TC、TG、LDLT、HSTRP水平均较对照组高,HDLT水平较对照组低,其中血TG、HDL-C、LDLT、HSTRP差异有统计学意义;患者组血脂异常(高TC、TG、HDL-C、LDL-C血)生均对,其中高TG、低HDLT发生率差异有统计学意义。血液HS-CRP水平与高TC、高TG、低HDLT血症的发生有关,与高LDL-C血症的发生无明显相关&结论慢性SZ患者存在明显的血脂代谢异常,血脂异常(高TC、高TG、低HDLT、高LDLT血症)的发生率高于一般正常人群,其中高TC、高TG、低HDLT血症的发生与HSTRP水平相关.

Objective To investigate the characteristics of blood lipid metabolism and is correlation with hypersen-sitive C-reactive protein(HS-CRP)in patients with chronic schizophrenia(SZ).Methods This study was a multi-center,cross-sectional study.Total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),serum HS-CRP level were recorded in 327 patients with chronie schizophrenia and 180 normal controls.The difference of serum lipids,HS-CRP levels and the incidence of dyslipi-demia were conpared between the patients group and the control group.The demographic data and clinical data of the patients were collected.The psychiatric symptoms were assessed by positive and negative syndrome scale(PAN-SS)and the risk factors of dyslipidemia were analyzed.The level of serum HS-CRP was measured and the correla-tion between HS-CRP level and dyslipidemia was analyzed.Results The serum TC,TG,LDL-C,HS-CRP level was higher in the patient group than that in the control group,and the HDL-C level in the patient group was lower than that in the control group,and the difference in blood TG,HDL-C,LDL-C,HS-CRP was stistically significant.The incidence of dyslipidemia(high TC,high TG,low HDL-C,and high LDL-C)in the patient group was higher than that in the control group,and there was a significant difference in the incidence of high TG,and low HDL-C.The level of HS-CRP in blood was related to the ocurrence of high TC,high TG,and low HDL-C,but not to the oc-.currence of hyperLDL-C.Conclusion There is significant dyslipidemia in patients with chronic schizophrenia,ir which the occurrence of high TC,high TG,and low HDL-C is related to the level of HS-CRP.