类风湿关节炎患者机体脂肪和肌肉成分分析

Analysis of body fat and muscle status in patients with rheumatoid arthritis

目的应用多频生物电阻抗分析法,探讨类风湿关节炎(RA)患者机体脂肪以及肌肉状况。方法选取RA患者353例(RA组)与年龄及性别相匹配的正常对照组343例(对照组),采用人体测量及多频生物电阻抗法测量两组的身高、体质量、体质指数(BMI)、腰围、臀围、体脂肪(BFM)、体脂百分比(PBF%)、内脏脂肪面积(VFA)、肌肉量(SLM)、去脂体质量(FFM),并根据四肢肌量计算身高校正后的四肢肌量。结果与对照组比较,RA组BFM、PBF%、VFA、肌少症发生率均显著增高(P<0.01);SLM、FFM、四肢肌量、身高校正的四肢肌量均显著降低(P<0.01);RA组在不同的BMI范围内肌少症的发生率均高于对照组(P<0.05),且在两组各自组内,随着BMI的增加,肌少症的发生率均呈下降趋势(P<0.01)&结论RA患者更容易出现脂肪增加以及肌肉减少,且肌少症的发生率随着BMI的增加而降低.

Objective To investigate the body fat and muscle status of patients with rheumatoid arthritis(RA)by multi-frequency bioelectrical impedance analysis.Methods A total of 353 RA patients(RA group)and 343 healthy subjects(control group)were selected.The height,body weight,W aist circunference,body fat(BFM),body fat percentage(PBF%o),visceral fat area(VFA),muscle mass(SLM),fat-free body weight(FFM),limb muscle mass of the two groups were measured by anthropometric and multi-frequency bioelectrical impedance meth-ods,and calculated body mass index(BMI)and the muscle mass of the limbs after height correction.Results Compared with the control group,the BFM of the RA group,PBF%,VFA,the incidence of sarcopenia were sig-nificantly increased(P<0.05);SLM,FFM,limb muscle mass,the height-corrected limb muscle mass was signifi-cantly decreased(P<0.05);within the two groups,with the increase of BMI,the ineidence of sarcopenia showed a declining trend,and the difference was statistically significant(P<0.05).Conclusion Patients with RA are more prone to increased fat and muscle loss,and the ineidence of sarcopenia decreases with increasing BMI.