乙醇体系中D-阿洛酮糖的结晶工艺优化

Crystallization Process Optimization of D-psicose in Ethanol System

为开发一套D-阿洛酮糖的结晶工艺,本文以乙醇为结晶体系,分别对影响结晶过程的4个主要因素(包括D-阿洛酮糖溶液的密度、乙醇与D-阿洛酮糖的比例、结晶时间和结晶温度)进行了单因素实验,并在单因素实验的基础上,采用响应曲面法对结晶的工艺参数进行优化。结果表明,最优操作条件为:D-阿洛酮糖溶液密度为1.35 g/mL,乙醇与D-阿洛酮糖溶液比例为3.8∶1,结晶时间为325 min,结晶温度为25℃。在此条件下,D-阿洛酮糖的初次结晶收率可达71.58%。以上结果可以得出结论:乙醇体系中可获得较高的D-阿洛酮糖结晶收率,本研究获得的模型可以用来优化D-阿洛酮糖在乙醇体系中的结晶过程。

In order to obtain crystallized D-psicose,a crystallization process of D-psicose in ethanol system was carried out. The effects of four main influencing factors(including density of D-psicose solution,the ratio of ethanol to D-psicose,crystallizing time and temperature)on recovery rate of D-psicose were tested. Based on these single factor experiments,response surface methodology was used to optimize crystallizing process. Results illustrated that the optimal operational conditions were as follow:Density of D-psicose solution was 1.35 g/mL,ratio of ethanol to D-psicose was 3.8∶1,crystallizing time and temperature were 325 min and 25 ℃. Under these conditions,the recovery rate was 71.58%. The above results illustrated that crystallized D-psicose could be obtained in ethanol system. Besides,the models obtained in this study could be used to optimize the crystallizing process of D-prisose in ethanol system.