神经节苷脂联合奥拉西坦治疗高血压性脑出血的临床观察

Clinical Observation of Ganglioside Combined with Oxiracetam in the Treatment of Hypertensive Cerebral Hemorrhage

目的比较高血压性脑出血患者单独应用奥拉西坦和联合应用奥拉西坦、神经节苷脂的临床疗效。方法以2015年1月至2017年12月于本院治疗的高血压性脑出血患者80例为研究对象,将其随机分为研究组和对照组各40例。研究组联合应用奥拉西坦及神经节苷脂,对照组单用奥拉西坦,分别治疗21 d,比较两组治疗前后的NIHSS评分、ADL评分、神经元特异烯醇化酶(NSE)和C反应蛋白(CRP)水平。结果两组患者治疗总有效率分别为92.50%、75.00%,研究组患者治疗效果优于对照组(χ^2=4.500,P=0.034);治疗前两组患者NIHSS评分、ADL评分差异无统计学意义,治疗后研究组患者各项评分均优于对照组(t=6.315、6.437,P=0.000);治疗后,研究组患者的NSE和CRP水平均低于对照组(t=5.845、16.859,P=0.000)。结论联合使用奥拉西坦和神经节苷脂能够明显缓解高血压性脑出血患者症状,改善神经元损伤和炎症反应,有效提高患者的认知功能和日常生活能力,临床效果较好。

Objective To compare the clinical efficacy of oxiracetam alone and oxiracetam combined with ganglioside in patients with hypertensive cerebral hemorrhage.Methods 80 patients with hypertensive cerebral hemorrhage treated in our hospital from January 2015 to December 2017 were selected as study subjects and randomly divided into the study group and the control group,with 40 cases in each group.Oxiracetam and ganglioside were combined in the study group,and oxiracetam alone was used in the control group for 21 days,respectively.NIHSS score,ADL score,levels of neuron-specific enolase(NSE)and C-reactive protein(CRP)in the two groups before and after treatment were compared.Results The total effective rate of the two groups was 92.50%and 75.00%,respectively.The treatment effect of the study group was significantly better than that of the control group(χ^2=4.50,P=0.034).There were no significant differences in NIHSS and ADL scores between the two groups before treatment,and all scores in the study group after treatment were significantly better than those in the control group(t=6.315,6.437,P=0.000).NSE and CRP levels in the study group were significantly lower than those in the control group(t=5.845,16.859,P=0.000).Conclusion Oracitan combined with ganglioside can significantly relieve the symptoms of patients with hypertensive cerebral hemorrhage,improve neuronal damage and inflammatory response,and effectively improve the patients’cognitive function and daily living ability,with good clinical effect.