脑立体定向深部核团毁损术对帕金森病患者生活质量的影响

Effect of Brain Stereotactic Deep Nucleus Derogation on Quality of Life in Patients with Parkinson’s Disease

目的探讨脑立体定向深部核团毁损术对帕金森病(PD)治疗效果及对患者生活质量的影响。方法选取2016年11月至2018年11月期间本院收治的PD患者92例,根据入院顺序进行排号,单号分为观察组(n=46),双号分为对照组(n=46)。对照组患者给予美多芭治疗,观察组患者在对照组基础上另行脑立体定向深部核团毁损术治疗。两组均连续治疗3个月。比较两组临床疗效,治疗前后帕金森病评价量表(UPDRS)运动症状、日常生活能力评分变化及帕金森病生活质量量表(PDQUALIF)评分变化,分析PDQUALIF评分与运动症状、日常生活能力评分的关系。结果观察组治疗有效率显著高于对照组(P<0.05);治疗后,观察组运动症状与日常生活能力评分均显著低于对照组(P<0.05);治疗后,观察组PDQUALIF量表评分显著低于对照组(P<0.05);PDQUALIF评分与运动症状评分呈正相关(r=0.673,P<0.05),与日常生活能力评分呈正相关(r=0.646,P<0.05)。结论脑立体定向深部核团毁损术可有效改善PD患者运动症状与日常生活能力,提高患者生活质量,且生活质量的提高与运动症状与日常生活能力改善呈正相关。

Objective To explore the treatment effect of brain stereotactic deep nucleus derogation on Parkinson s disease(PD)and its effect on the life quality of the patients with this disease.Methods A total of 92 patients with PD admitted to the hospital from November 2016 to November 2018 were selected.After numbered according to their admission sequence,they were divided into two groups:observation group with patients of odd number(n=46)and control group with patients of even number(n=46).The control group was given Madopar(pramipexole),and the observation group received brain stereotactic deep nucleus derogation on this basis.Both groups were treated continuously for 3 months.The clinical efficacy,united Parkinson s disease rating scale(UPDRS)motor symptoms before and after treatment,the changes of daily living ability score and Parkinson s disease quality of life scale(PDQUALIF)score before and after treatment were compared between the two groups.The relationship among PDQUALIF score and motor symptoms,score of daily living ability was analyzed.Results The effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).After treatment,the scores of motor symptoms and daily living ability in the observation group were significantly lower than those in the control group(P<0.05).After treatment,the PDQUALIF scale score in observation group was significantly lower than that in control group(P<0.05).PDQUALIF score was positively correlated not only with the score of motor symptoms(r=0.673,P<0.05),but also with the score of daily living ability(r=0.646,P<0.05).Conclusion Brain stereotactic deep nucleus derogation can effectively improve the motor symptoms and daily living ability and enhance the quality of life of the patients with PD.The improvement of quality of life is positively correlated with the improvement of motor symptoms and daily living ability.