牙周炎中T细胞受体CDR3谱系研究进展

Research progress on the T cell receptor CDR3 spectral sequence of periodontitis

牙周炎是一种由菌斑微生物引发的牙周支持组织的慢性炎症性、破坏性疾病,其发生、发展与宿主的免疫应答密切相关,其中T细胞在牙周炎免疫应答中发挥着重要作用。本文将从T细胞免疫应答及T细胞受体(T cell receptor,TCR)互补决定区3(complementarity⁃determining region 3,CDR3)谱系特征着手,对TCR CDR3谱系特征与牙周炎发病的关系作一综述,为牙周炎的发病机制研究及临床个性化治疗提供新思路。对牙周炎TCR CDR3谱系的文献复习提示,牙周炎局部病变中存在T细胞的寡克隆积累及V(variable)、J(join⁃ing)基因的偏向取用,且在CDR3区发现重复取用的核苷酸序列及保守的氨基酸基序,提示TCR CDR3组库的特征在牙周炎免疫发病机制中具有重要作用。

Periodontitis is a chronic inflammatory and destructive disease of periodontal support tissue initiated by plaque microorganisms,and its pathogenesis and progression are closely related to the immune response of the host,in which T cells play an important role in the periodontitis immune response.This article will start with the T cell immune response and the characteristics of the T cell receptor complementarity⁃determining region 3(TCR CDR3)spectrum and will review the relationship between the characteristics of the TCR CDR3 spectrum and the pathogenesis of periodontitis to provide some new ideas for the studies of pathogenesis and the clinical personalized treatment of periodontitis.The study on the TCR CDR3 spectrum of periodontitis by reviewing the literature suggests that there is an oligoclonal accu⁃mulation of T cells and biased access of Variable(V)and Joining(J)genes in local lesions of periodontitis;moreover,the repeated use of nucleotide sequences and a conservative amino acid motif were found in the CDR3 region,which suggests that the characteristics of the TCR CDR3 group library play an important role in the immune pathogenesis of periodontitis.