牙髓切断术与冠髓再生的研究进展

Research progress of pulpotomy and crown pulp regeneration

冠髓再生是一种以干细胞和支架结构代替盖髓剂,并将其置于牙髓切断术后的健康根髓组织断面上,最终使牙冠部分的牙髓⁃牙本质复合体得以再生的方法。本文以牙髓切断术为背景,就冠髓再生的意义、生理学基础及其应用与挑战作一综述,以期为牙髓再生相关研究提供新思路。文献复习结果表明,将传统的牙髓切断术与干细胞生物学和组织工程学相结合,利用健康根髓的组织修复潜能进行冠髓再生,能有效地促进牙本质和部分牙髓再生。近年随着牙髓再生相关研究的深入,其面临的诸多挑战也逐渐显露,不仅需要筛选出能够安全有效地促进牙髓干细胞增殖分化的处理方式,还要继续探索适用于髓室结构、功能多元化的支架材料。

Crown pulp regeneration is a method to replace the pulp⁃capping agent with stem cells and scaffold struc⁃tures,which are placed on the section of healthy root pulp tissue after pulpotomy to regenerate the pulp⁃dentin complex in the crown.This paper reviews the significance,physiological basis,application and challenges of crown pulp regener⁃ation to provide new ideas for the study of pulp regeneration.The results of a literature review show that the combina⁃tion of traditional pulpotomy,stem cell biology and tissue engineering,as well as the regeneration of crowns and pulp by using the tissue repair potential of healthy root pulp can effectively promote the regeneration of dentin and parts of pulp.In recent years,with the development of research on pulp regeneration,many challenges have been gradually revealed.It is necessary not only to select the treatment methods that can promote the proliferation and differentiation of dental pulp stem cells safely and effectively but also to continue to explore the scaffold materials suitable for the structural and functional diversity of the pulp chamber.