埃索美拉唑联合莫沙必利对反流性食管炎患者食管动力学的影响分析

Effect of Esomeprazole Combined with Mosapride on Esophageal Motility in Patients with Reflux Esophagitis

目的探讨埃索美拉唑联合莫沙必利对反流性食管炎患者食管动力学的影响。方法收集2018年1月~2019年2月来本院就诊的56例反流性食管炎患者的病历资料,按患者就诊顺序单双号对其进行分组,单号者28例归为对照组,采用奥美拉唑联合莫沙必利治疗,双号者28例归为观察组,采用埃索美拉唑联合莫沙必利治疗。对比分析两组的临床治疗效果差异,观察两组治疗后食管动力学变化。结果观察组治疗总有效率96.43%,明显高于对照组的78.57%,差异有统计学意义(P<0.05);治疗后观察组患者的食管括约肌压力明显高于对照组,卧位反流时间百分比、立位反流时间百分比和总反流时间百分比显著低于对照组,差异有统计学意义(P<0.05);治疗后观察组患者的生活质量评分明显高于对照组患者,差异有统计学意义(P<0.05)。结论反流性食管炎患者给予埃索美拉唑联合莫沙必利治疗可取得较理想的疗效,有助于患者食管动力学状态的改善及生活质量的提高。

Objective To investigate the effect of esomeprazole combined with mosapride on esophageal dynamics in patients with reflux esophagitis.Methods Medical records of 56 patients with reflux esophagitis who came to our hospital from January 2018 to February 2019 were collected.According to the order of patients,the patients were divided into single and double numbers.28 patients in the single group were treated with omeprazole and mosapride,and 28 patients in the double group were treated with esomeprazole combined with mosapride.Lee treatment.The difference in effect between the two groups was compared.Results The total effective rate of treatment in the observation group was 96.43%,which was significantly higher than the total effective rate in the control group’s 78.57%,The difference between the two groups was significant(P<0.05);After treatment,the esophageal sphincter pressure in the observation group was significantly higher than that in the control group.The percentage of regurgitation time,the percentage of standing reflux time and the total The percentage of reflux time was significantly lower than that of the control group,The difference between the two groups was significant(P<0.05);the quality of life score of the observation group was significantly higher than that of the control group after treatment,The difference between the two groups was significant(P<0.05).Conclusion Esomeprazole combined with mosapride in patients with reflux esophagitis can achieve better results,which can improve the esophageal dynamics and improve the quality of life.