维生素C联合碳酸氢钠在食管碘染色检查中的临床研究

Vitamin C combined with sodium bicarbonate in examination of esophageal iodine staining

目的探讨维生素C联合碳酸氢钠在食管碘染色检查中对抗碘对食管的腐蚀性副作用的有效性。方法选取200例食管碘染色患者,随机分为对照组(A组,n=100)和实验组(B组,n=100)。B组染色观察后,以维生素C生理盐水冲洗食管、胃底,再取胃底内液体测pH值;吸净液体后,用碳酸氢钠生理水溶剂冲洗食管,再用生理盐水冲洗食管和胃底,取胃底内液体测pH值。A组用生理盐水冲洗食管胃底。记录麻醉清醒时、24和72 h咽喉部不适、烧心和胸腹痛情况,并进行比较。招募40例经食管碘染色的患者,20例为A组处理方法(C组,n=20),20例为B组处理方法(D组,n=20),72 h内复查胃镜,记录C和D组胃底黏膜糜烂评分,并进行比较。结果B组较A组麻醉清醒时、24和72 h咽喉部不适、烧心和胸腹痛发生率明显降低,差异均有统计学意义(P<0.01);B组用维生素C处理后的pH值与用碳酸氢钠后的pH值比较,差异有统计学意义(P<0.01);D组与C组比较,72 h内胃底黏膜糜烂程度较轻,两组胃底黏膜糜烂评分比较,差异有统计学意义(P<0.01)。结论维生素C联合碳酸氢钠对抗食管碘染色后碘对食管胃底黏膜腐蚀性副作用安全、有效,可在临床上推广应用。

Objective To explore the effect of vitamin C combined with sodium bicarbonate in examination of esophageal iodine staining in patients with esophageal corrosive side effects.Methods 200 patients with esophageal iodine staining were randomly divided into control group(group A,n=100)and experimental group(group B,n=100).After esophageal iodine staining in group B,the esophagus and the bottom of the stomach were washed with the solvent of vitamin C tablets were dissolved in saline and the pH of the liquid in the stomach was detected,then,the liquid was aspirated,the esophagus was washed with the solvent of sodium bicarbonate tablets were dissolved in saline,the esophagus and the stomach were washed with saline,and then,the pH of the liquid in the stomach was detected.While,in group A,the esophagus and the stomach was washed with saline.The events of patients about throat discomfort;heartburn,chest and abdominal pain were recorded at 0 h,24 h and 72 h when the patient was awake after anesthesia.40 patients had been treated with esophageal iodine staining were divided into group C with the treatment way with patients in group A(group C,n=20)and group D with the treatment way with patients in group B(group D,n=20).Gastroscope was reviewed within 72 h,and respective score of mucosal erosion of bottom of the stomach was recorded in group C and D.Results Compared with group A,the respective incidences of throat discomfort,heartburn,chest and abdominal pain were significantly lower in group B at 0 h,24 h and 72 h.there was statistically significant respectively(P<0.01).In group B,the pH value was lower before using sodium bicarbonate than after that(P<0.01).Compared with group C,the average score of mucosal erosion of bottom of the stomach was lower in group D(P<0.01).Conclusion Vitamin C combined with sodium bicarbonate are used treatment the corrosive side effects of iodine after esophageal iodine staining are safe and effective,for it can be widely clinical application.