口服维生素D辅助治疗小儿支气管哮喘的效果观察

Observation of effects of oral vitamin D in adjuvant treatment of children with bronchial asthma

目的:观察口服维生素D辅助治疗小儿支气管哮喘的效果。方法:选取100例支气管哮喘患儿作为研究对象,按照随机数字表法将其分为对照组和观察组各50例,对照组给予布地奈德治疗,观察组在对照组的基础上联合口服维生素D辅助治疗,比较治疗前后两组血清白细胞介素-2(IL-2)、肿瘤坏死因子-α(TNF-α)水平、哮喘控制情况、肺功能指标水平及不良反应发生情况。结果:治疗后观察组IL-2、TNF-α水平明显低于对照组,哮喘控制率及1秒用力呼气容积(FEV1)、呼气峰值流速(PEF)、FEV1/用力肺活量(FVC)水平均明显高于对照组,差异均有统计学意义(P<0.05);观察组不良反应发生率为4.00%(2/50),明显低于对照组的22.00%(11/50),差异有统计学意义(P<0.05)。结论:与单用布地奈德相比,布地奈德联合维生素D辅助治疗小儿支气管哮喘的效果更显著,可有效改善患儿的症状及肺功能,且不良反应少。

Objective: To observe effects of oral vitamin D in treatment of children with bronchial asthma. Methods: 100 children with bronchial asthma were selected as the research subjects. According to the random number table method, they were divided into control group(n=50) and observation group(n=50). The control group was treated with Budesonide, while the observation group was treated with oral vitamin D on the basis of that of the control group. The serum IL-2 and TNF-α levels, asthma control, lung function indexes, and adverse reactions were compared between the two groups before and after the treatment. Results: After the treatment, the levels of IL-2 and TNF-α in the observation group were significantly lower than those in the control group;the asthma control rate and the levels of FEV1, PEF, FEV1/FVC were significantly higher than those in the control group;and the differences were statistically significant(P<0.05). The incidence of adverse reactions in the observation group was 4.00%(2/50), which was significantly lower than 22.00%(11/50) in the control group, and the difference was statistically significant(P<0.05). Conclusions: Compared with single Budesonide, Budesonide combined with vitamin D in the treatment of the children with bronchial asthma is more effective. It can effectively improve the symptoms and lung function with fewer adverse reactions.