穴位注射防治肿瘤放化疗后白细胞减少症文献Meta分析

Literature Meta-analysis of Acupoint Injection in the Prevention and Treatment of Leukopenia after Radiotherapy and Chemotherapy

目的系统评价穴位注射防治肿瘤放化疗后白细胞减少症的临床疗效和不良反应。方法纳入中文和英文的文献,通过计算机检索中国知网(CNKI)数据库、万方、维普、中国生物医学文献数据库(CBM)、Pubmed、Embase、Cochrane Library。以穴位注射防治肿瘤放化疗后不良反应的随机对照临床研究(Randomized controlled trial,RCT)为对象,2名研究员独立进行文献筛选,资料提取,并对所纳入的文献质量评价后,采用Revman 5.3进行Meta分析。结果最终纳入11篇文献,共计767例患者,发现:与其他疗法相比,穴位注射能缓解肿瘤放化疗后重度骨髓抑制[OR=4.58,95%CI(2.72,7.70)P<0.05];改善患者的骨髓抑制[OR=2.11,95%CI(1.45,3.08)P<0.05];升高患者外周血的白细胞[MD=1.10,95CI%(0.61,1.59)P<0.05]。且所纳入的11篇文献未见不良反应。结论穴位注射安全性相对较高,并且能缓解肿瘤放化疗后重度骨髓抑制,改善患者的骨髓抑制,升高患者外周血的白细胞。

Objective To systematically evaluate the clinical efficacy and adverse reactions of acupoint injection in the prevention and treatment of leukopenia after radiotherapy and chemotherapy.Methods Chinese and English literatures were included.CNKI database,Wanfang,Weipu,CBM,pubmed,EMBASE and Cochrane library were searched by computer.Randomized controlled trial(RCT)of acupoint injection in the the prevention and treatment of adverse reactions after radiotherapy and chemotherapy was used as the research object.Two researchers independently screened the literature,extracted the data,and evaluated the quality of the included literature.Revman 5.3 was used for meta-analysis.Results A total of 767 patients were included in 11 literatures.It was found that acupoint injection could alleviate severe bone marrow depression after radiotherapy and chemotherapy[OR=4.58,95%CI(2.72,7.70)P<0.05],improve bone marrow depression[OR=2.11,95%CI(1.45,3.08)P<0.05],and increase peripheral blood leukocytes[MD=1.10,95 CI%(0.61,1.59)P<0.05].There were no adverse reactions in 11 literatures.Conclusion Acupoint injection is relatively safe and can alleviate severe bone marrow depression,improve bone marrow depression and increase peripheral blood leukocytes in patients with cancer after radiotherapy and chemotherapy.