珠及膏治疗特发性肺纤维化气阴两伤型临床观察

Clinical Observation on Zhuji Ointment in the Treatment of Idiopathic Pulmonary Fibrosis of Impairment of both Qi and Yin Type

目的评价珠及膏对特发性肺纤维化(气阴两伤型)患者临床症状改善、肺功能及6 min步行试验的影响。方法以2015年10月—2017年12月在北京康益德中西医结合肺科医院就诊的79例特发性肺纤维化患者为研究对象,按随机数字表法分为治疗组及对照组,治疗组在原有治疗基础上加用膏方治疗,对照组维持原有治疗方案。观察2组患者治疗前后的中医证候积分、肺功能(CO弥散量)及6 min步行试验变化情况。结果治疗组总有效率89.74%,优于对照组,治疗组患者治疗后的中医证候评分明显降低(P<0.05),6 min步行距离增加(P<0.05),较对照组差异有统计学意义(P<0.05)。结论珠及膏联合西医治疗特发性肺纤维化(气阴两伤型)具有良好的临床疗效。

Objective To evaluate the effect of Zhuji ointment on the improvement of clinical symptoms,pulmonary function and 6-minute walking test in patients with idiopathic pulmonary fibrosis of impairment of both qi and yin type.Methods 79 patients with idiopathic pulmonary fibrosis,who were treated in our hospital from October 2015 to December 2017,were randomly divided into the treatment group and the control group according to the random number table.The treatment group was treated with ointment on the basis of the original treatment,and the control group was treated with ointment on the basis of the original treatment.The control group maintained the original treatment scheme.The changes of TCM symptom score,pulmonary function(CO diffusion capacity)and 6-minute walking test were observed before and after treatment in the two groups.Results The total effective rate of the treatment group was 89.74%,which was better than that of the control group.The TCM symptom score of the treatment group was significantly lower than that of the control group(P<0.05),and the walking distance of 6 minutes was increased(P<0.05).There was significant difference between the two groups(P<0.05).Conclusion Zhuji ointment combined with western medicine has a good clinical effect in the treatment of idiopathic pulmonary fibrosis of impairment of both qi and yin type.