米非司酮联合甲氨蝶呤与单纯甲氨蝶呤治疗宫外孕的临床疗效比较分析

Comparative Analysis of Clinical Efficacy of Mifepristone Combined with Methotrexate and Methotrexate in the Treatment of Ectopic Pregnancy

目的米非司酮联合甲氨蝶呤与单纯甲氨蝶呤治疗宫外孕的临床疗效比较。方法选取该院在2016年10月—2019年9月接收的60例宫外孕患者进行试验,将以上患者根据停经时间、妊娠位置随机分成两组进行对比实验。通过两组不同的治疗方案治疗患者,观察患者的治疗效果。同时还应当观察两组患者使用不同治疗方案之后不良反应发生的情况。最后观察两组患者治疗后的指标值。结果通过实验组的治疗方案,成功治疗例数为29例,所占比例为96.67%,采用对照组的治疗方案,成功治疗例数为21例,所占比例为70.00%,实验组的治疗方案明显比对照组要好,差异有统计学意义(χ2=4.007,P<0.05);两组实验患者的不良反应发生的比例差异无统计学意义(χ2=1.298,P>0.05);通过实验组治疗方案治疗的患者,她们的包块消除时间、腹痛消失时间、阴道止血时间都比对照组患者要好很多,实验组的治疗方案相对较好,差异有统计学意义(t=6.832、6.752、11.112,P<0.05)。结论通过米非司酮联合甲氨蝶呤治疗宫外孕效果非常显著,由此可见,将两种药物联合使用的治疗方法效果非常好,可以被广泛使用。

Objective To compare the clinical efficacy of mifepristone combined with methotrexate and methotrexate alone in the treatment of ectopic pregnancy.Methods 60 patients with ectopic pregnancy admitted to the hospital from October 2016 to September 2019 were enrolled in the study.The above patients were randomly divided into two groups according to menopause time and pregnancy position for comparative experiments.The patients were treated by two different treatment regimens to observe the patient's therapeutic effect.At the same time,it should be observed that the adverse reactions occurred after the two groups of patients used different treatment regimens.Finally,the index values of the two groups of patients after treatment were observed.Results Through the treatment plan of the experimental group,the number of successful treatments was 29 cases,accounting for 96.67%.The treatment plan of the control group was 21 cases,and the proportion of successful treatment was 70.00%.The treatment plan of the experimental group was significantly better than that of the control group,the difference was statistically significant(χ2=4.007,P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups of patients(χ2=1.298,P>0.05);patients treated by the experimental group treatment regimen,their mass elimination time,abdominal pain disappearance time,vaginal hemostasis time are much better than the control group patients,the experimental group of treatment is relatively better.,the difference was statistically significant(t=6.832,6.752,11.112,P<0.05).Conclusion The effect of mifepristone combined with methotrexate in the treatment of ectopic pregnancy is very significant.It can be seen that the combination of the two drugs is very effective and can be widely used.