黑蒜对便秘模型小鼠的润肠通便功能

Laxative Effect of Black Garlic on Constipation Mice

目的:研究黑蒜对便秘模型小鼠的润肠通便功能的影响。方法:将昆明小鼠随机分为空白组、模型组、阳性组和低、中、高3个剂量的给药组。灌胃7 d后,通过对小鼠小肠推进功能和排便功能的研究,得到黑蒜对便秘模型小鼠的小肠推进率、首次排便时间、6 h内排便粒数、粪便总质量及粪便性状的影响。结果:研究发现3个剂量组与模型组和阳性组比较,各指标都有显著性差异,表明黑蒜能明显提高便秘模型小鼠的小肠内容物推进率,缩短首次排黑便时间,增加6 h内排黑便粒数、质量及提高粪便含水量。结论:黑蒜对便秘模型小鼠具有良好的润肠通便作用。

Objective:To investigate the effect of black garlic on lubricating bowel and on the defecation function of constipation mice.Methods:Kunming mice were randomly divided into control group,model control group,positive control group and low,medium-and high-dose treatment groups.After continuous intragastric administration for 7 days,through applying small intestinal propelling test and defecation test in mice to observe the effect of the black garlic,the percentage of propellant in small intestine,the time of the first dejection,the dejection amount and weights in six hours and the stool shape were observed.Results:All the tested parameters differed significantly between each dose of black garlic infusion and either the model group or the positive control group.It could apparently improve the percentage of propellant in intestinal peristalsis,shorten the time of the first black dejection,increase feces amount and weights in six hours and improve the water content of mice feces.Conclusion:The black garlic had the laxative effect in constipation mice.