辛开苦降甘补调和法治疗老年晚期非小细胞肺癌的临床研究

Study on Effects of XinKai-KuJiang-GanBu Therapy in Treating Senile Patients with Advanced Non-small Cell Lung Cancer

目的:研究辛开苦降甘补调和法对老年晚期非小细胞肺癌的治疗效果。方法:纳入符合条件患者60例,随机分为治疗组及对照组各30例。治疗组和对照组均采用西医常规姑息治疗,治疗组联合采用辛开苦降甘补调和法中药内服,疗程均为4周。治疗后比较2组的近期疗效、证候变化、体力状态、中位生存期。结果:治疗组和对照组在肿瘤客观控制率(CR+PR)及临床受益率(CR+PR+SD)方面差异无统计学意义(P>0.05)。治疗组胸痛、咯血、纳差症状改善优于对照组(P<0.05),乏力改善明显优于对照组(P<0.01),体力状态改善优于对照组(P<0.05);治疗组中位生存期为301±15 d,优于对照组的258±34 d(P<0.05)。结论:辛开苦降甘补调和法能缓解老年晚期肺癌临床症状,改善患者体力状态,延长生存时间,可进一步开展研究。

Objective:To study the therapeutic effects of the XinKai-KuJiang-GanBu method in treating senile patients with advanced NSCLC.Methods:60 patients were randomly divided into two groups.These 30 patients in the treatment group were treated with the Shengjiang-yifei decoction based on the XinKai-KuJiang-GanBu therapy combined with conventional therapy and those 30 patients in the control group were treated with conventional therapy alone,the therapeutic effect were evaluated 4 weeks after treatment.Results:There were significant improvements in some correlative symptoms,including hemoptysis,chest pain,fatigue and loss of appetite.In addition,the clinical study showed better therapeutic effects on improving physical strength and median survival time in the treatment group than those in the control group.Conclusion:Combination of the of XinKai-KuJiang-GanBu therapy with conventional therapy has better effect on suppressing tumor than that in conventional therapy alone.