伊维菌素吡喹酮咀嚼片溶出度方法的建立

Establishment of Dissolution Test Method of Ivermectin and Praziquantel Chewable Tablets

为了建立同时测定伊维菌素吡喹酮咀嚼片两种主药溶出度的测定方法,采用高效液相色谱法测定在不同pH值溶出介质、不同浓度表面活性剂和不同转速的条件下伊维菌素吡喹酮咀嚼片两种主药的溶出曲线,确定了伊维菌素吡喹酮咀嚼片的溶出方法.结果显示,三批样品45 min时伊维菌素、吡喹酮两种主药的溶出度均大于85%.建立的溶出度测定方法可用于伊维菌素吡喹酮咀嚼片溶出度的测定.

The article established a method to simultaneously determine the dissolution of two main ingredients of ivermectin and praziquantel chewable tablets.The method was determined by the dissolution curves of ivermectin and praziquantel which were tested by high performance liquid chromatography method in different kinds of dissolution mediums at different rotation speeds.The dissolution of ivermectin and praziquantel in three batches of samples were above 85%at 45 minute.This method can be used for determining the dissolution of ivermectin and praziquantel chewable tablets.