扶正清热复方联合常规疗法治疗急性吉兰-巴雷综合征疗效观察

Effects of Fuzheng Qingre Formula Combined with Routine Therapy on Acute Guillain-Barré Syndrome

目的观察扶正清热复方联合常规疗法治疗急性吉兰-巴雷综合征(GBS)的疗效。方法选择74例急性GBS患者,按随机数字表分为治疗组(37例)和对照组(37例)。两组均采用常规疗法,治疗组加用扶正清热复方,治疗1个月。采用Barthel指数评定患者日常生活能力(ADL),采用Hughes方法评定患者肢体运动功能、感觉功能,观察两组总体疗效。结果治疗组脱落2例,对照组脱落9例。与本组治疗前比较,两组治疗后ADL评分升高(P<0.05),肢体运动功能及感觉功能改善(P<0.05),对照组治疗后正中神经远端运动潜伏期(DML)降低(P<0.05),正中神经运动传导速度(MCV)、尺神经感觉传导速度(SCV)及感觉神经动作电位(SNAP)升高(P<0.05);治疗组正中神经及尺神经DML降低(P<0.05),正中神经及尺神经MCV、SCV升高(P<0.05)。与对照组同期比较,治疗组ADL评分升高(P<0.05),肢体运动功能及感觉功能改善(P<0.05),正中神经DML降低(P<0.05),正中神经MCV、SCV及尺神经MCV升高(P<0.05)。治疗组疗效优于对照组(χ^2=6.806,P<0.01)。结论扶正清热复方联合常规疗法治疗急性GBS较常规疗法可获得更好的效果。

Objective To explore the efficacy of Fuzheng Qingre Formula(FQF) combined with routine therapy on acute Guillain-Barr6 syndrome(GBS).Methods Totally 74 patients with GBS were recruited and assigned to two groups by random digits table:the experimental group(37 cases) and the control group(37 cases).Both groups were treated with routine therapy for 1 month,and the experimental group took FQF additionally.The patients’ activity of daily living(ADL) was evaluated by Barthel index,the patients’ body movement function and sensory function was evaluated by Hughes method.The overall efficacy of the two groups was observed.Results Two cases dropped out in the experimental group,9 cases dropped out in the control group.Compared with baseline,both groups showed a significantly improved efficiency in ADL score,motor function score and sensory function(P <0.05);the distal motor latency(DML) of median nerve was decreased(P <0.05),motor conduction velocity(MCV)of median nerve,sensory conduction velocity(SCV)and sensory nerve action potential(SNAP)of ulnar nerve were increased in the control group(P <0.05);DML of median nerve and ulnar nerve were decreased(P <0.05),while MCV and SCV of median nerve and ulnar nerve were increased in the treatment group(P <0.05).Compared with the control group,ADL score was increased(P <0.05),motor function and sensory function were improved(P <0.05),DML of median nerve was decreased(P <0.05),MCV and SCV of median nerve were increased(P <0.05),SCV of ulnar nerve was increased in the treatment group(P <0.05).The effect of treatment group was better than that of control group(χ^2=6.806,P <0.01).Conclusion FQF combined with routine therapy for acute GBS is more effective than routine therapy.