CD68因子在白血病中的研究进展

Research progress of the CD68 factor in leukemia

CD68因子是一种在外周血单核细胞和巨噬细胞中高度表达的蛋白质,是单核巨噬细胞主要抗原之一,又称CD68抗原、GP110、巨噬细胞黏蛋白(Macrosialin)、清道夫受体D1(Scavenger Receptor Class D,Member 1,SCARD1)和LAMP4,是血液系统的黏蛋白(mucin)样分子家族、溶酶体/核内体相关膜糖蛋白LAMP家族和清道夫受体家族的成员之一。肿瘤微环境中的巨噬细胞称为肿瘤相关巨噬细胞(TAMs),参与肿瘤增殖、血管生成、浸润、转移及化疗抵抗。在血液系统恶性疾病中,巨噬细胞广泛浸润到淋巴瘤、骨髓瘤、白血病等恶性细胞累及的组织中,被恶性微环境异常活化,获得了特异的活化表型,并参与疾病进展。在白血病中其名称引申为白血病相关巨噬细胞、急性白血病相关巨噬细胞或者“保姆样细胞”。本文综述了白血病中CD68因子的研究进展。

CD68 is a highly expressed protein in peripheral blood monocytes and macrophages,and is one of the major antigens of monocytes and macrophages,also known as CD68 antigen,GP110,Macrosialin,Scavenger Receptor Class D,Member 1(SCARD1)and LAMP4.It is a member of mucin-like molecular family of blood system,lysosomal/endosomal related membrane glycoprotein LAMP family and scavenger receptor family.Macrophages in the tumor microenvironment are called tumor-associated macrophages(TAMs),which are involved in tumor proliferation,angiogenesis,infiltration,metastasis and chemotherapy resistance.In malignant diseases of the blood system,macrophages are widely infiltrated into lymphoma,myeloma,leukemia and other tissues involved by malignant cells.They are activated by abnormal malignant microenvironment,can obtain specific activation phenotypes,and participate in disease progression.In leukemia,its name is extended to leukemia-related macrophages,acute leukemia-related macrophages or"nurse-like cells".This paper reviews the research progress of CD68 factor in leukemia.