二氢卟吩类光敏剂在光动力疗法治疗恶性肿瘤中的研究进展

The development of chlorin-based photosensitizers in photodynamic therapy for malignant tumor

肿瘤的治疗是目前医学领域最为棘手的难题之一,患者多采用手术、放化疗相结合的综合治疗方式。与传统抗癌疗法相比,光动力疗法最突出的优点是能选择性杀灭局部肿瘤而不危及正常组织。光敏剂作为光动力疗法中至关重要的因素,它的研究受到越来越多的重视。本文就近年来二氢卟吩类光敏剂在光动力疗法治疗恶性肿瘤中的研究进展作一简要综述。

The treatment of tumors is one of the most difficult problems in the medical field.Patients are treated by a combination method of surgery,radiotherapy and chemotherapy.The most prominent advantage of photodynamic therapy(PDT)is that it can selectively kill local tumors without endangering normal tissues.As a crucial factor in PDT,the study of photosensitizers has received more and more attention.In this paper,chlorin-based photosensitizers in PDT for malignant tumors were reviewed.