晚期原发性肝细胞癌的药物治疗

Drug therapy of advanced primary hepatocellular carcinoma

原发性肝癌(PLC)是临床上常见的消化系统恶性肿瘤之一,90%以上为肝细胞癌(HCC)。大多数原发性肝细胞癌患者存在肝炎基础疾病,肝功能差,局部治疗后易复发,确诊时已到晚期,进展快,预后极差。晚期原发性肝细胞癌系统治疗包括基础肝病治疗、系统化疗、分子靶向治疗、免疫治疗,本文就晚期原发性肝细胞癌的系统化疗、分子靶向治疗、免疫治疗作一综述。

Primary liver cancer is one of the most common malignant tumor of the digestive system,and more than 90%of which is hepatocellular carcinoma.Most of the patients with primary hepatocellular carcinoma have basic liver hepatitis,poor liver function,and easy to relapse after local treatment.And their diagnosis was advanced with rapid progress,accordingly,and the prognosis is extremely poor.The systemic therapy of advanced primary hepatocellular carcinoma includes basic liver disease treatment,systemic chemotherapy,molecular targeting therapy and immunotherapy.This article is a review of systemic chemotherapy,molecular targeting therapy and immunotherapy for advanced primary hepatocellular carcinoma.