miR-210/VMP1信号传导通路在脑胶质瘤中作用的研究进展

The research progress of microRNA-210/VMP1 signal transduction pathway in glioma

脑胶质瘤是目前临床上最常见的中枢神经系统恶性肿瘤之一,全球发病率约为每年7/10万。在我国胶质瘤的发病率占据颅内肿瘤第一位。临床上胶质瘤的治疗手段主要为手术切除,但是术后复发率高、生存期短,通常只有15~19个月。因此对于胶质瘤寻找有效的治疗靶点,在临床上就显得尤为重要。有研究表明胶质瘤患者脑组织中miR-210水平明显高于正常脑组织,且表达越高患者预后越差。空泡膜蛋白1(vacuole membrane protein 1,VMP1)为大分子跨膜蛋白,研究发现VMP1在蛋白分泌、细胞器形成及多细胞发育过程中起重要作用,另外在人体许多肿瘤组织中如乳腺癌、肾癌、肝癌等均有表达,且在原发与转移性肿瘤中表达不一致,被预测其可能是一个肿瘤相关蛋白,但其在胶质瘤中的机制目前仍未涉及到。故本文简要综述当前miR-210/VMP1信号传导通路在胶质瘤中作用机制的研究进展。

Glioma is one of the most common malignant tumors of the central system.The global incidence rate is about 7/100000 per year.In China,the incidence of glioma occupies the first place among intracranial tumors.Surgical resection is the main treatment for glioma,but the recurrence rate is high and the survival time is short,usually only 15 to 19 months.Therefore,it is particularly important to find effective therapeutic targets for glioma.Some studies have shown that miR-210 levels in glioma patients are significantly higher than those in normal brain tissue,and the higher the expression,the worse the prognosis of glioma patients.It was found that VMP1 plays an important role in protein secretion,organelle formation and multicellular development.Additionally,it is expressed in many tumor tissues of human body such as breast cancer,kidney cancer,liver cancer,etc.The expression of VMP1 in primary and metastatic tumors is inconsistent.It is predicted that VMP1 may be a tumor-related protein,but its mechanism in glioma has not yet been involved.Therefore,this paper briefly reviews the current research progress of miR-210/VMP1 signaling pathway in glioma.