摘要
血液系统恶性疾病患者的侵袭性真菌病(IFD)发病率较高,其中以急性髓细胞白血病(AML)/骨髓增生异常综合征(MDS)患者,以及接受异基因造血干细胞移植(allo-HSCT)治疗者最为常见.IFD是影响血液系统恶性疾病患者预后的重要因素,该病诊断困难、疗效差,抗真菌治疗始于预防.目前,关于IFD化学预防的临床指征、药物、给药时间及疗效等仍存在争议.笔者拟就血液系统恶性疾病患者IFD的流行病学特点、发病危险因素、药物防治疗效等方面的研究进展进行综述.
The incidence of invasive fungal disease (IFD)is high in patients with hematological malignancies,including those with acute myeloid leukemia(AML)/myelodysplastic syndrome(MDS),and those receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT ).IFD is an important prognostic factor in patients with hematological malignancies.IFD is difficult to diagnose,and the efficacy of treatment is poor.Therefore,antifungal treatment begins with prevention.At present,there are still controversies about the clinical indications,drugs,administration time and efficacy of IFD chemoprevention. This article intends to review the research progress on the epidemiology and risk factors of IFD,as well as the clinical outcomes of antifungal agents for antifungal prophylaxis in patients with hematological malignancies.
作者
赵元萁
冯四洲
Zhao Yuanqi;Feng Sizhou(State Key Laboratory of Experimental Hematology,National Clinical Research Center for Blood Diseases,Institute of Hematology&Blood Diseases Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin 300020,China)
出处
《国际输血及血液学杂志》
CAS
2019年第6期548-552,F0003,共6页
International Journal of Blood Transfusion and Hematology
基金
中国医学科学院创新工程(2016-12M-1-017)
天津市自然科学基金(18JCZDJC34400)
中央级公益性科研院所基本科研业务费专项资金(2018PT32034)。
关键词
抗真菌药
血液肿瘤
流行病学研究
化学预防
侵袭性真菌病
Antifungal agents
Hematologic neoplasms
Epidemiologic studies
Chemoprevention
Invasive fungal disease
