摘要
综述睡眠-觉醒机制的相关因素及中药对其调节的研究进展。随着神经解剖学、药理学、分子生物学等技术方法的发展,发现睡眠-觉醒机制与众多因素有关,如下丘脑-垂体-肾上腺轴、褪黑素、多巴胺、5-羟色胺、神经肽、乙酰胆碱、γ-氨基丁酸能等;加味四逆散、加味逍遥散等中药可通过调节激素水平及神经递质影响睡眠-觉醒机制。
The relevant factors in sleep-awakening mechanism and research progress in its regulation with Chinese medicine are reviewed. With the development of neuroanatomy, pharmacology and molecular biology, it has been found that sleep-awakening mechanism is related to many factors, such as the thalamus-pituitary-adrenal axis, the melatonin system, dopamine, 5-hydroxytryptamine, neuropeptide, acetylcholine and gamma-aminobutyric acid etc. Recipes in TCM like Modified Sini Powder and Modified Xiaoyao Powder can influence the sleep-awakening mechanism by regulating hormone levels and neurotransmitters.
作者
李怿霞
徐建
李欧
沙中玮
李志敏
LI Yixia;XU Jian;LI Ou;SHA Zhongwei;LI Zhimin(Sleep Research Institute,Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200070,China)
出处
《上海中医药杂志》
2019年第12期89-92,共4页
Shanghai Journal of Traditional Chinese Medicine
基金
上海市科委科研计划项目(17ZR1428100)
上海市科委项目(19401935600)
上海市卫计委重点薄弱学科中医老年病学资助项目(2015ZB0504)
上海市卫计委青年项目(20174Y0038)
上海中医药大学中医学学科项目
关键词
睡眠-觉醒节律
中医药疗法
分子神经生物学
调节机制
综述
sleep-awakening rhythm
therapy in traditional Chinese medicine
molecular neurobiology
regulatory mechanisms
review
