血小板抗体检测分析与探讨

Analysis platelet antibody detection

目的 为提升临床血小板输注有效率,对需要输注血小板的患者进行抗体检测与分析,探讨血小板抗体产生的影响因素,降低血小板无效输注的发生率。方法 采用固相凝集法对47例有输血史或/和妊娠史的患者(观察组)进行血小板抗体检测,并随机选择各科无输血史和妊娠史的患者(对照组)32例作为对照;同时对输血≤3次、>3次的患者血小板抗体阳性率进行分析统计。结果 观察组血小板抗体阳性率(14.89%)高于对照组(0%),P<0.05;输血>3次血小板抗体阳性率(31.25%)、≤3次(7.69%),P<0.05,两组比较均有统计学意义。结论 血小板输注前进行抗体检测,可让临床提前进行干预,降低血小板无效输注的几率;有输血史或/和妊娠史的患者、输血>3次的患者容易产生血小板抗体。

Objective To improve the effectiveness of platelet transfusion,we detected and analyzed the platelet antibody in patients whom need to transfuse platelet.We investigate the effect of anti-platelet antibodies production,so as to reduce the incidence of platelet transfusion refractoriness.Methods Using solid agglutination method to detect platelet antibody in 47 cases(observation group)within transfusion history or/and pregnancy history.And select 32 cases within no transfusion history or pregnancy history as control group.Analyze the platelet antibody positive rate of cases which transfusion bellow 3 times and above 3 times.Results The platelet antibody positive rate of observation group(14.89%)is higher than control group(0%),P<0.05,respectively.The platelet antibody positive rate of transfusedabove-3-times(31.25%)is higher than transfused-bellow-3-times(7.69%),P<0.05,respectively.Conclusion Detecting the platelet antibody before the transfusion can reduce the probability of platelet transfusion refractoriness and allow clinical to intervene.Patients who have transfusion history or/and pregnancy history or transfuse above 3 times are more easily creating platelet antibodies.