手术切除联合液氮冷冻治疗皮肤鳞状细胞癌患者的临床疗效观察

Clinical effect of microsurgical operation combined with liquid nitrogen cryotherapy on squamous cell carcinoma in elderly patients

目的探讨手术切除联合液氮冷冻治疗皮肤鳞状细胞癌的临床疗效。方法选取2011年1月至2014年7月本院皮肤科收治的皮肤鳞状细胞癌患者46例,按照随机对照法将其分为观察组和对照组,每组23例。对照组给予显微外科手术治疗。观察组给予显微外科手术联合液氮冷冻治疗,术后随访1~3年,比较两组患者临床疗效、1年复发率、1年转移率及生存率。结果观察组治疗总有效率高于对照组(91.3%>82.6%)(P<0.05)。观察组患者1年复发率为17.4%,转移率为8.7%;对照组患者1年期复发率为13.4%,转移率为4.3%,观察组患者1年期复发率及转移率均低于对照组(P<0.05)。结论外科手术联合液氮冷冻治疗皮肤鳞状细胞癌,可以明显降低术后癌细胞的复发率、转移率,同时延长患者生存时间,因而值得进一步研究以及推广。

Objective To investigate the clinical effect of microsurgical operation combined with liquid nitrogen cryotherapy on squamous cell carcinoma in elderly patients.Methods Forty-six patients with squamous cell carcinoma visiting dermatology department of our hospital from January 2011 to July 2014 were enrolled.They were randomizely divided into two groups:the control group(n=23)receiving a microsurgical treatment and the observation group(n=23)receiving liquid nitrogen cryotherapy as add-on to a microsurgical operation.All patients were followed up for 1-3 years.Clinical efficacy,1-year recurrence rate,1-year transfer rate and the survival rate were compared between the two groups.Results The total effective rate was higher in the observation group than in the control group(91.3%vs.82.6%,P<0.05).The 1-year recurrence rate and 1-year transfer rate were lower in the observation group than in the control group(13.4%vs.17.4%,4.3%vs.8.7%,P<0.05).Conclusions The surgery combined with liquid nitrogen cryotherapy for cutaneous squamous cell carcinoma can significantly reduce the recurrence rate and transfer rate after operation and prolong the survival time,which is worthy of further research and promotion.