摘要
TGR5受体是G蛋白偶联受体家族(G protein-coupled receptors,GPCRs)中的成员。TGR5受体在人类和动物中的许多组织如肾、肝、胃、小肠、肺等中都处于高表达,其中在胎盘和脾中的表达最高。TGR5不仅是胆汁酸的受体,也可以被其他的一些合成激动剂所激活介导一系列的信号通路,参与机体的生理和病理过程,如4-苯氧基-烟酰胺或4-苯氧基-嘧啶-5-甲酰胺化合物、6α-乙基-23(S)-甲基-胆酸(6-EMCA,INT-777)等。本文主要综述了TGR5受体在二型糖尿病、肥胖、炎症、癌症及肝脏再生等疾病发生发展中的作用。
TGR5 receptor is a member of G protein-coupled receptors(G protein-coupled receptors,GPCRs).The TGR5 receptor is highly expressed in many tissues of humans and animals,such as kidney,liver,stomach,intestine,lung,but its expression is the highest in the placenta and spleen.TGR5 is not only a bile acids receptor but also can be activated by other synthetic agonists to mediate a lot of signaling pathways in the physiological and processes,such as 4-phenoxy-nicotinamide or 4-phenoxy-pyrimidine-5-carboxamide compound,6α-ethyl-23(S)-methyl-cholic acid(6-EMCA,INT-777),etc.This article mainly focuses on summarizing the role of TGR5 receptors in the development of diseases such as type 2 diabetes,obesity,inflammation,cancer,and liver regeneration.
作者
祁有朝
李培锋
QI You-chao;LI Pei-feng(College of Veterinary,Medicine,Inner Mongolia Agricultural University,Hohhot 010018,China;Key Laboratory of Clinical Diagnosis and Treatment Techniques for Animal Disease,Ministry of Agriculture,Hohhot 010018,China)
出处
《中国兽医科学》
CAS
CSCD
北大核心
2019年第12期1580-1585,共6页
Chinese Veterinary Science
基金
国家自然科学基金面上项目(31272605)
