桂枝茯苓胶囊联合孕三烯酮治疗卵巢子宫内膜异位囊肿的临床研究

Clinical study on Guizhi Fuling Capsules combined with gestrinone in treatment of ovarian endometriosis cyst

目的探讨桂枝茯苓胶囊联合孕三烯酮胶囊治疗卵巢子宫内膜异位囊肿的临床疗效。方法选取2017年4月-2018年9月在迁安燕山医院接受手术治疗的86例卵巢子宫内膜异位囊肿患者为研究对象,采用随机数字表法将86例患者分为对照组和治疗组,每组各43例。对照组患者在术后第1天口服孕三烯酮胶囊,1粒/次,第3天服用第2次,2次/周,之后在每周的相同时间内服药。治疗组患者在对照组治疗的基础上口服桂枝茯苓胶囊,3粒/次,3次/d。两组患者连续治疗6个月。观察两组的临床疗效,比较两组的卵巢基质动脉血流动力学、性激素水平、血清因子水平。结果治疗后,对照组和治疗组的总有效率分别为79.07%、95.35%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者收缩期血流峰值速度(PSV)、搏动指数(PI)、动脉直径(D)值均较治疗前升高,阻力指数(RI)值较治疗前降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组卵巢基质动脉血流动力学指标明显优于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者的血清促黄体生成素(LH)、促卵泡刺激素(FSH)水平均较治疗前升高,雌二醇(E2)、孕酮(P)水平均较治疗前降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组患者性激素水平明显优于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者血清癌抗原125(CA125)、血清癌抗原199(CA199)、血管内皮生长因子(VEGF)水平均较治疗前显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗组患者血清因子水平明显低于对照组(P<0.05)。结论桂枝茯苓胶囊联合孕三烯酮胶囊治疗卵巢子宫内膜异位囊肿具有较好的临床效果,可减轻临床症状,促进卵巢功能恢复,具有一定临床推广应用价值。

Objective To investigate the effect of Guizhi Fuling Capsules combined with Gestrinone Capsules in treatment of ovarian endometriosis cyst. Methods Patients(86 cases) with ovarian endometriosis cyst undergoing surgical treatment in Qianan Yanshan Hospital from April 2017 to September 2018 were randomly divided into control and treatment groups, and each group had 43 cases. Patients in the control group were po administered with Gestrinone Capsules on the first day, 1 grain/time, then taken it for the second time on the third day, twice weekly. Patients in the treatment group were po administered with Guizhi Fuling Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 6 months. After treatment, the clinical efficacies were evaluated, and ovarian stromal artery hemodynamics, sex hormone levels, and serum factor levels in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 79.07% and 95.35%, respectively, and there was difference between two groups(P < 0.05). After treatment, PSV, PI, and D in two groups were significantly increased, but the RI in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). And the ovarian stromal artery hemodynamics indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups(P < 0.05). After treatment, the levels of LH and FSH in two groups were significantly increased, but the levels of E2 and P in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). And sex hormone levels in the treatment group were significantly better than those in the control group, with significant difference between two groups(P < 0.05). After treatment, the levels of CA125, CA 199 and VEGF in two groups were significantly decreased, and the difference was significant in the same group(P < 0.05). And the serum factor levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups(P < 0.05). Conclusion Guizhi Fuling Capsules combined with Gestrinone Capsules has clinical curative effect in treatment of ovarian endometriosis cyst, can alleviate clinical symptoms, and promote the recovery of ovarian function, which has a certain clinical application value.