肺叶支气管堵塞时非球形微米粒子在人体上呼吸道中的沉降

Deposition of Non-spherical Micro-particles in Human Upper Respiratory Tract when Lobar Bronchi Obstructed

在真实的人体上呼吸道模型中模拟了正常情况和肺叶支气管堵塞时的流场和粒子沉降.利用粒子形状因子研究了平静呼吸和肺叶支气管堵塞情况下上呼吸道流场分布以及球形微米粒子和非球形微粒子的沉降.肺叶支气管的堵塞情况分为左肺叶支气管堵塞、右肺叶支气管堵塞、左上、左下、右上、右中、右下肺叶支气管堵塞7种情况.非球形粒子的形状因子越小,沉降率越高;肺叶支气管堵塞时会影响流场分布,增加粒子人体上呼吸道内整体沉降率,且明显影响粒子的沉降部位;一侧肺叶支气管堵塞基本不会改变主气管及以上部位的粒子的沉降却能明显增加其它支气管的粒子的沉降;进一步表明微米粒子在人体上呼吸道内的沉降机制主要以拖拽作用下的惯性撞击为主.

Based on a realistic human upper respiratory tract model, particle shape factor was adopted to study the deposition of micro-particles when lobar bronchi obstructed. The fluid field and deposition of non-spherical micro-particles was studied in human upper respiratory tract when lobar bronchi obstructed.There is a difference in the fluid field of the normal situation and the obstructed situation, and which affected the movement and deposition of the particles. The depositions of different particle shape factor was studied and the total deposition and each part of the URT was investigated. The less the particle shape factor is, the easier the particles deposited, which means the deposition fraction of micro-particle in the human upper respiratory tract is affected by the particle shape and which is related to the drag force.