规范使用肠溶阿司匹林相关研究进展

Research advances in regular enteric-coated aspirin regimen

小剂量阿司匹林是防治以动脉粥样硬化为基础的心、脑血管疾病的基石。文献分析显示,鉴于阿司匹林肠溶制剂的特点,服药时间与不良反应密切相关,建议以晚餐前半小时服用肠溶阿司匹林,以最大限度发挥阿司匹林的抗血小板效应并尽可能减少不良反应的发生概率;同时对于处于高度应激状态以及已有胃、十二指肠溃疡的患者,建议联用质子泵抑制剂。

Low-dose aspirin is the cornerstone of prevention and treatment of cardiovascular and cerebrovascular diseases based on atherosclerosis.In view of the characteristics of aspirin enteric-coated preparations,the time of taking medicine is closely related to the adverse reactions.It is recommended to take enteric-coated aspirin at half an hour before dinner so as to maximize the antiplatelet effect of aspirin and minimize the incidence of adverse reactions.At the same time,for patients in high stress state and with gastric and duodenal ulcers,combination of proton pump inhibitors is proposed.