可必特与普米克令舒治疗哮喘性支气管炎的临床疗效分析

Analysis of the clinical efficacy of Combivent and Pulmicort in the treatment of asthmatic bronchitis

目的研究吸入用复方异丙托溴铵溶液(商品名:可必特)与吸入用布地奈德混悬液(商品名:普米克令舒)治疗哮喘性支气管炎的临床效果。方法72例哮喘性支气管炎患者,采用抽签法分为观察组和对照组,各36例。对照组采用普米克令舒进行治疗,观察组在对照组基础上联合可必特进行治疗。对比两组患者症状体征消退时间、血气指标、住院时间与治疗效果。结果观察组气喘消退时间、哮鸣音消退时间、咳嗽消退时间、肺啰音消退时间及住院时间均短于对照组,差异有统计学意义(P<0.05)。治疗后,两组动脉血氧分压与血氧饱和度均高于治疗前,动脉血二氧化碳分压低于治疗前,且观察组动脉血氧分压与血氧饱和度均高于对照组,动脉血二氧化碳分压低于对照组,差异均有统计学意义(P<0.05)。观察组总有效效率97.22%高于对照组的83.33%,差异有统计学意义(P<0.05)。结论哮喘性支气管炎患者采用可必特联合普米克令舒治疗能明显改善临床症状,且治疗效果显著。

Objective To study the clinical effect of compound ipratropium bromide solution for inhalation(trade name:Combivent)and budesonide suspension for inhalation(trade name:Pulmicort)in the treatment of asthmatic bronchitis.Methods A total of 72 asthmatic bronchitis patients were divided into observation group and control group by lottery method,with 36 cases in each group.The control group was treated by Pulmicort,and the observation group was treated by Combivent on the basis of the control group.The disappearance time of symptoms and signs,blood gas index,hospitalization time and therapeutic effect was compared between the two groups.Results The disappearance time of asthma,wheeze,cough,rale and hospitalization time in the observation group was shorter than those in the control group,and their difference was statistically significant(P<0.05).After treatment,the arterial oxygen partial pressure and oxygen saturation in the two groups was higher than those before treatment,and arterial carbon dioxide partial pressure was lower than that before treatment.The arterial oxygen partial pressure and oxygen saturation in the observation group was higher than those in the contorl group,and arterial carbon dioxide partial pressure was lower than that in the control group.Their difference was statistically significant(P<0.05).The total effective rate 97.22%in the observation group was higher than 83.33%in the control group,and the difference was statistically significant(P<0.05).Conclusion Combivent and Pulmicort shows remarkable effect in the treatment of patients with asthmatic bronchitis,and it can significantly improve their clinical symptoms.