血清脂质运载蛋白2、骨代谢指标与中年女性骨密度相关性研究

Correlation between serum lipocalin 2, bone metabolic markers and bone mineral density in middle-aged women

目的观察血清脂质运载蛋白2(lipocalin 2,LCN2)、骨代谢指标与中年女性骨密度的相关性。方法分析253名汉族女性资料,通过双能X线吸收测定法测量其腰椎和股骨颈的骨密度(bone mineral density,BMD),测量LCN2、I型胶原的羧基末端交联端肽(type I collage cross-linked-telopeptide,CTX)、骨钙蛋白(osteocalcin,OCN)和肌酸酐(screatinine,Scr)的血清水平。结果LCN2与腰椎和股骨颈的BMD呈负相关。LCN2和CTX、OCN、年龄、Scr之间呈显著正相关。调整年龄和Scr后,LCN2、BMDs和OCN之间的相关性消失,但LCN2仍与CTX呈正相关。LCN2的血清浓度在有和没有骨质疏松性骨折的受试者之间没有显示出显著差异。在多变量回归分析中,LCN2是血清CTX变化的主要决定因素之一。结论在中年女性中,血清LCN2水平、BMD和OCN之间的关系受到年龄和Scr的干扰。虽然LCN2与CTX呈正相关,但相关性非常小。

Objective The correlation between serum lipid transporter 2(LCN2),bone metabolic markers and bone mineral density in middle-aged women was observed.Methods This cross-sectional study analyzed 253 previously enrolled Han Chinese women.BMDs of the lumbar spine and femoral neck were measured using dual energy X-ray absorptiometry.Serum levels of lipocalin 2(LCN2),carboxy-terminal cross-linking telopeptide of type-1 collagen(CTX),osteocalcin(OCN)and serum creatinine(Scr)were measured.Results LCN2 was inversely correlated with BMDs at the lumbar spine and femoral neck.A significant positive correlation between LCN2 and CTX,OCN,age,and Scr was also observed.After adjusting for age and Scr,the correlation among LCN2,BMDs and OCN disappeared,but LCN2 was still positively associated with CTX.The circulating concentration of LCN2 showed no significant difference between subjects with and without osteoporotic fractures.In multivariate regression analysis,LCN2 was one of the main determinants for changes in serum CTX.Conclusion In women,the relationships among serum LCN2 level,BMDs,and OCN were confounded by age and Scr.Although LCN2 was positively correlated with CTX,the correlation was very weak.