脂肪肝患者25-羟维生素D与骨密度和代谢综合征相关性研究

Correlation between 25-hydroxyvitamin D and bone mineral density and metabolic syndrome in patients with fatty liver

目的通过分析维生素D水平对脂肪肝患者代谢综合征(MetS)的影响,为MetS和低骨密度(BMD)的治疗提供基础数据。方法通过肥胖指数和血液指标分析了150名诊断为脂肪肝的成年人的MetS比率和血清25-羟基维生素D[25(OH)D]水平。收集了有关人口统计学因素,营养摄入量,生活习惯的数据以及髋部和腰椎(L_1-L_4)骨密度。结果所有受试者的平均25(OH)D水平为14 ng/mL,不足和缺乏率分别为36.0%和31.3%。MetS的比例为38.0%,MetS组的平均25(OH)D水平为12.1 ng/mL。MetS组低密度脂蛋白胆固醇、三酰甘油和血糖均高于正常组,男性腰围明显高于正常组。血清25(OH)D下降,骨密度下降。MetS患者骨密度明显低于非MetS患者(P<0.05)。结果表明,维生素D水平越低,MetS风险越高,骨密度越低。结论血清25(OH)D水平可能是脂肪肝患者MetS和低骨密度的危险因素。

Objective To provide basic data for the management of metabolic syndrome(MetS)and bone mineral density(BMD)by analyzing the effect of vitamin D levels on MetS in patients with fatty liver.Methods We analyzed the MetS ratio and serum 25-hydroxy-vitamin D(25[OH]D)concentration in 150 adults diagnosed with fatty liver by using obesity index and blood profiles.We collected data of demographic factors,nutrient intake,lifestyle habits,and BMD of the hip and lumbar spine(L1-L4).Results The mean 25(OH)D concentration of all subjects was 14 ng/mL.The insufficiency and deficiency rates were 36.0%and 31.3%.The proportion of MetS was 38.0%and the mean 25(OH)D level in MetS group was 12.1 ng/mL.Low-density lipoprotein cholesterol,triglyceride,and blood glucose were higher in the MetS group than in the normal group.The waist circumference of the male was significantly higher than that in the normal group.Serum 25(OH)D and BMD decreased.BMD in MetS patients was significantly lower than that in non-MetS patients(P<0.05).The results showed that the lower the vitamin D concentration,the higher the risk of MetS and low BMD.Conclusion These results suggest that serum 25(OH)D levels may be a risk factor for MetS and low BMD in patients with fatty liver.