血液灌流治疗内毒素血症机理及研究进展

Mechanism and research status of hemoperfusion in endotoxemia treatment

内毒素血症是由于血液中细菌或病灶内细菌释放出大量内毒素至血液而引起的一种病理生理表现。其会引起多器官衰竭、发生不可逆休克甚至造成死亡,具有较高的死亡率。细菌内毒素则是引起内毒素血症的主要因素,目前临床上尚缺乏安全有效的药物用于治疗内毒素血症。研究结果表明,通过血液净化方法可有效降低血液中内毒素水平,从而达到治疗内毒素血症的目的。探讨了内毒素血症的致病机理,介绍了血液灌流治疗技术的发展,不同血液灌流吸附树脂吸附内毒素的机理和研究现状以及用于治疗内毒素血症的血液灌流吸附材料的性能和安全性要求,旨在为治疗内毒素血症合成新型血液灌流吸附材料提供理论支持。

Endotoxemia is a pathophysiological manifestation caused by the release of large amounts of endotoxin from bacteria in the blood or in the lesion.It can cause multiple organ failure,irreversible shock,and even death.The mortality rate of endotoxemiaIt is high.Bacterial endotoxin is the main cause of endotoxemia.At present,there is no safe and effective drug to treat endotoxemia in clinic.Research shows that blood purification can effectively reduce endotoxin level in the blood,then achieve the goal of treatment of endotoxemia.In this paper,the pathogenesis of endotoxemia,the development of hemoperfusion therapy technology,the mechanism and research status of endotoxin adsorption by different hemoperfusion resin were discussed,and the performance and safety requirements of hemoperfusion adsorbent materials for endotoxemia treatment were studied,so as to provide theoretical support for the synthesis of new hemoperfusion adsorption materials for the treatment of endotoxemia.