2型糖尿病患者免疫球蛋白G N-糖基与红细胞分布宽度的相关性研究

Association of immunoglobulin G N-glycans and red blood cell distribution width in patients with type 2 diabetes mellitus

目的探索2型糖尿病患者免疫球蛋白G N-糖基与红细胞分布宽度的关系,为疾病变化的联合标志物的研究提供基础。方法选取2014年11月至2017年9月北京市小汤山医院进行体检的社区人群,纳入2型糖尿病患者429例。采用超高压液相色谱法检测免疫球蛋白G N-糖基组。免疫球蛋白G N-糖基与红细胞分布宽度的相关分析应用Spearman秩相关及多元线性逐步回归模型。结果多元线性逐步回归分析显示,2型糖尿病患者GP14(t=-2.640,P=0.009);GP13(t=3.065,P=0.003);GP11(t=-3.454,P=0.001)及GP2(t=2.264,P=0.025)与红细胞分布宽度具有独立相关关系。结论2型糖尿病患者中免疫球蛋白G N-糖基与红细胞分布宽度可能存在关联,为疾病变化的联合标志物的研究提供基础。

Objective To explore the relationship between the immunoglobulin G N-glycans and red blood cell distribution width(RWD)in patients with type 2diabetes mellitus(T2DM),so as to provide scientific basis for the study of combined biomarkers.Methods A total of 429patients with T2DM were recruited into the study from November 2014to September 2017.The immunoglobulin G N-glycans were detected by high performance liquid chromatography(HPLC).Spearman rank correlation analysis and multiple linear stepwise regression models were used to analyze the association between immunoglobulin G N-glycans and RDW.Results Multiple linear stepwise regression analysis showed that GP14(t=-2.640,P=0.009),GP13(t=3.065,P=0.003),GP11(t=-3.454,P=0.001)and GP2(t=2.264,P=0.025)were independently associated with RDW.Conclusions Immunoglobulin G N-glycans might be associated with RDW in patients with T2DM,which may provide the basis for the combined biomarkers study.