高龄妇女供精人授助孕后子代安全性的随访分析

Follow-up analysis on the children′s safety of after artificial insemination with donor sperm

目的研究高龄妇女供精人授助孕后子代安全性。方法本研究使用随机数字表法选择2007-06/2014-06在我中心行供精人授助孕(AID)的高龄(>35周岁)妊娠妇女196例纳入研究组,并选择同期我中心行供精人授助孕的≤35周岁妊娠妇女120例作为对照组,采用SPSS软件进行统计分析,以a=0.05作为检验水准,随访时间为2年,观察两组妊娠情况与子代安全。结果两组患者AID手术时基本情况均无明显差异(t=-1.668、-0.662、-1.173,=0.096、0.508、0.242);两组新生儿在2周岁体重、走路时间、说话时间、2周岁身高、2周岁MDI、2周岁PDI上无明显差异(t=0.294、0.610、0.575、1.009、0.000、0.478,P=0.769、0.543、0.566、0.314、1.000、0.633),P>0.05;研究组妊娠相关并发症11.73%高于对照组4.17%,手术分娩率19.90%高于对照组6.67%(χ~2=3.905、7.597,P=0.048、0.006),差异有统计学意义,P<0.05。结论随着年龄的增长,高龄妇女供精助孕整体情况较差,子代安全性较低,临床意见早期妊娠,提高新生儿健康水平,值得应用。

Objective:To make the follow-up analysis on the children′s safety after artificial insemination with donor sperm(AID).Methods:196 advanced(>35 years old)pregnant women underwent AID in our center from June 2007 to June 2014 were selected(research group);120 cases pregnant women(≤35 years old)underwent AID were selected(control group).SPSS software was applied;a=0.05 was taken to be significant level.After 2 y of follow-up,the pregnancy conditions and children′s safety were studied.Results:The basic operation conditions between groups were not significantly different(t=-1.668,-0.662,-1.173;P=0.096,0.508,0.242);the body weight for children aged 2,initial walking time and talking time as well as height MDI(mental development index)and PDI(psychomotor development index for children aged 2 between groups were not significantly different(t=0.294,0.610,0.575,1.009,0.000,0.478;P=0.769,0.543,0.566,0.314,1.000,0.633)Pregnancy-associated complications in the research group(11.73%)was higher than that in the control group(4.17%);the surgical delivery rate in the research group(19.90%)was higher than that in the control group(6.67%).(χ~2=3.905,7.597;P=0.048,0.006).Conclusion:Over age,the overall AID conditions are worsened with lower children′s safety.Therefore,the early pregnancy is good to improve children′s health.